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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/58110
Title: Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: A meta-analysis
Authors: Charat Thongprayoon
Nadeen J. Khoury
Tarun Bathini
Narothama Reddy Aeddula
Boonphiphop Boonpheng
Ploypin Lertjitbanjong
Kanramon Watthanasuntorn
Napat Leeaphorn
Supavit Chesdachai
Aldo Torres-Ortiz
Wisit Kaewput
Jackrapong Bruminhent
Michael A. Mao
Wisit Cheungpasitporn
University of Minnesota Twin Cities
UMKC School of Medicine
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
The University of Arizona
Indiana University School of Medicine-Evansville
Henry Ford Hospital
Mayo Clinic
University of Mississippi Medical Center
The Mary Imogene Bassett Hospital
Mayo Clinic in Jacksonville, Florida
East Tennessee State University
Keywords: Medicine
Issue Date: 1-Jul-2020
Citation: Urology Annals. Vol.12, No.3 (2020), 241-247
Abstract: © 2020 Urology Annals | Published by Wolters Kluwer-Medknow. Background: Persistent anemia has been described in kidney transplant (KTx) recipients with parvovirus B19 virus infection. However, the epidemiology of parvovirus B19 and parvovirus B19-related anemia after KTx remains unclear. We conducted this systematic review (1) to investigate the incidence of parvovirus B19 infection after KTx and (2) to assess the incidence of parvovirus B19 among KTx patients with anemia. Materials and Methods: A systematic review was conducted in EMBASE, MEDLINE, and Cochrane databases from inception to March 2019 to identify studies that reported the incidence rate of parvovirus B19 infection and/or seroprevalence of parvovirus B19 in KTx recipients. Effect estimates from the individual studies were extracted and combined using random-effects, generic inverse variance method of DerSimonian and Laird. The protocol for this systematic review is registered with PROSPERO (no. CRD42019125716). Results: Nineteen observational studies with a total of 2108 KTx patients were enrolled. Overall, the pooled estimated seroprevalence of parvovirus B19 immunoglobulin G was 62.2% (95% confidence interval [CI]: 45.8%-76.1%). The pooled estimated incidence rate of positive parvovirus B19 DNA in the 1st year after KTx was 10.3% (95% CI: 5.5%-18.4%). After sensitivity analysis excluded a study that solely included KTx patients with anemia, the pooled estimated incidence rate of positive parvovirus B19 DNA after KTx was 7.6% (95% CI: 3.7%-15.0%). Among KTx with anemia, the pooled estimated incidence rate of positive parvovirus B19 DNA was 27.4% (95% CI: 16.6%-41.7%). Meta-regression analysis demonstrated no significant correlations between the year of study and the incidence rate of positive parvovirus B19 DNA (P = 0.33). Egger's regression asymmetry test was performed and demonstrated no publication bias in all analyses. Conclusion: The overall estimated incidence of positive parvovirus B19 DNA after KTX is 10.3%. Among KTx with anemia, the incidence rate of positive parvovirus B19 DNA is 27.4%. The incidence of positive parvovirus B19 DNA does not seem to decrease overtime.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/58110
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089123039&origin=inward
ISSN: 09747834
09747796
Appears in Collections:Scopus 2020

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