Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/58118
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMatthew Mollen_US
dc.contributor.authorPhuwanat Sakornsakolpaten_US
dc.contributor.authorNick Shrineen_US
dc.contributor.authorBrian D. Hobbsen_US
dc.contributor.authorDawn L. DeMeoen_US
dc.contributor.authorCatherine Johnen_US
dc.contributor.authorAnna L. Guyatten_US
dc.contributor.authorMichael J. McGeachieen_US
dc.contributor.authorSina A. Ghariben_US
dc.contributor.authorMa'en Obeidaten_US
dc.contributor.authorLies Lahousseen_US
dc.contributor.authorSara R.A. Wijnanten_US
dc.contributor.authorGuy Brusselleen_US
dc.contributor.authorDeborah A. Meyersen_US
dc.contributor.authorEugene R. Bleeckeren_US
dc.contributor.authorXingnan Lien_US
dc.contributor.authorRuth Tal-Singeren_US
dc.contributor.authorAni Manichaikulen_US
dc.contributor.authorStephen S. Richen_US
dc.contributor.authorSungho Wonen_US
dc.contributor.authorWoo Jin Kimen_US
dc.contributor.authorAh Ra Doen_US
dc.contributor.authorGeorge R. Washkoen_US
dc.contributor.authorR. Graham Barren_US
dc.contributor.authorBruce M. Psatyen_US
dc.contributor.authorTraci M. Bartzen_US
dc.contributor.authorNadia N. Hanselen_US
dc.contributor.authorKathleen Barnesen_US
dc.contributor.authorJohn E. Hokansonen_US
dc.contributor.authorJames D. Crapoen_US
dc.contributor.authorDavid Lynchen_US
dc.contributor.authorPer Bakkeen_US
dc.contributor.authorAmund Gulsviken_US
dc.contributor.authorIan P. Hallen_US
dc.contributor.authorLouise Wainen_US
dc.contributor.authorMaría Soler Artigasen_US
dc.contributor.authorVictoria E. Jacksonen_US
dc.contributor.authorDavid P. Strachanen_US
dc.contributor.authorJennie Huien_US
dc.contributor.authorAlan L. Jamesen_US
dc.contributor.authorShona M. Kerren_US
dc.contributor.authorOzren Polaseken_US
dc.contributor.authorVeronique Vitarten_US
dc.contributor.authorJonathan Martenen_US
dc.contributor.authorIgor Rudanen_US
dc.contributor.authorMika Kähönenen_US
dc.contributor.authorIda Surakkaen_US
dc.contributor.authorChristian Giegeren_US
dc.contributor.authorStefan Karraschen_US
dc.contributor.authorRajesh Rawalen_US
dc.contributor.authorHolger Schulzen_US
dc.contributor.authorIan J. Dearyen_US
dc.contributor.authorSarah E. Harrisen_US
dc.contributor.authorStefan Enrothen_US
dc.contributor.authorUlf Gyllenstenen_US
dc.contributor.authorMedea Imbodenen_US
dc.contributor.authorNicole M. Probst-Henschen_US
dc.contributor.authorTerho Lehtimäkien_US
dc.contributor.authorOlli T. Raitakarien_US
dc.contributor.authorClaudia Langenbergen_US
dc.contributor.authorJian'an Luanen_US
dc.contributor.authorNick Warehamen_US
dc.contributor.authorJing Hua Zhaoen_US
dc.contributor.authorCaroline Haywarden_US
dc.contributor.authorAlison Murrayen_US
dc.contributor.authorDavid J. Porteousen_US
dc.contributor.authorBlair H. Smithen_US
dc.contributor.authorMarjo Riitta Jarvelinen_US
dc.contributor.authorMatthias Wielscheren_US
dc.contributor.authorPeter K. Joshien_US
dc.contributor.authorKatherine A. Kentistouen_US
dc.contributor.authorPaul RHJ Timmersen_US
dc.contributor.authorJames F. Wilsonen_US
dc.contributor.authorJames P. Cooken_US
dc.contributor.authorLars Linden_US
dc.contributor.authorAnubha Mahajanen_US
dc.contributor.authorAndrew P. Morrisen_US
dc.contributor.authorRalf Ewerten_US
dc.contributor.authorGeorg Homuthen_US
dc.contributor.authorBeate Stubbeen_US
dc.contributor.authorStefan Weissen_US
dc.contributor.authorEleftheria Zegginien_US
dc.contributor.authorScott T. Weissen_US
dc.contributor.authorEdwin K. Silvermanen_US
dc.contributor.authorFrank Dudbridgeen_US
dc.contributor.authorMartin D. Tobinen_US
dc.contributor.authorMichael H. Choen_US
dc.contributor.otherNational Jewish Healthen_US
dc.contributor.otherGlaxoSmithKline, USAen_US
dc.contributor.otherUniversity Hospital of Ghenten_US
dc.contributor.otherUniversiteit Genten_US
dc.contributor.otherUniversity of Leicesteren_US
dc.contributor.otherErasmus MCen_US
dc.contributor.otherUniversity of Virginia School of Medicineen_US
dc.contributor.otherQueen's Medical Centreen_US
dc.contributor.otherUniversitetet i Bergenen_US
dc.contributor.otherUniversity of Washington School of Medicineen_US
dc.contributor.otherUniversity of Colorado at Denver Anschutz Medical Campusen_US
dc.contributor.otherColumbia University Irving Medical Centeren_US
dc.contributor.otherUniversity of Virginiaen_US
dc.contributor.otherKaiser Permanenteen_US
dc.contributor.otherBrigham and Women's Hospitalen_US
dc.contributor.otherUniversity of Washington, Seattleen_US
dc.contributor.otherSeoul National Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherThe University of British Columbiaen_US
dc.contributor.otherUniversity of Colorado at Denveren_US
dc.contributor.otherThe University of Arizonaen_US
dc.contributor.otherGlenfield Hospitalen_US
dc.contributor.otherJohns Hopkins Universityen_US
dc.contributor.otherHarvard Medical Schoolen_US
dc.contributor.otherKangwon National Universityen_US
dc.date.accessioned2020-08-25T10:34:40Z-
dc.date.available2020-08-25T10:34:40Z-
dc.date.issued2020-07-01en_US
dc.identifier.citationThe Lancet Respiratory Medicine. Vol.8, No.7 (2020), 696-708en_US
dc.identifier.issn22132619en_US
dc.identifier.issn22132600en_US
dc.identifier.other2-s2.0-85087427951en_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/58118-
dc.description.abstract© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COPD and associated phenotypes. Methods: We constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and FEV1/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV1/FVC <0·7 and FEV1 <80% of predicted). Associations were tested using logistic regression models, adjusting for age, sex, height, smoking pack-years, and principal components of genetic ancestry. We assessed predictive performance of models by area under the curve. In a subset of studies, we also studied quantitative and qualitative CT imaging phenotypes that reflect parenchymal and airway pathology, and patterns of reduced lung growth. Findings: The polygenic risk score was associated with COPD in European (odds ratio [OR] per SD 1·81 [95% CI 1·74–1·88] and non-European (1·42 [1·34–1·51]) populations. Compared with the first decile, the tenth decile of the polygenic risk score was associated with COPD, with an OR of 7·99 (6·56–9·72) in European ancestry and 4·83 (3·45–6·77) in non-European ancestry cohorts. The polygenic risk score was superior to previously described genetic risk scores and, when combined with clinical risk factors (ie, age, sex, and smoking pack-years), showed improved prediction for COPD compared with a model comprising clinical risk factors alone (AUC 0·80 [0·79–0·81] vs 0·76 [0·75–0·76]). The polygenic risk score was associated with CT imaging phenotypes, including wall area percent, quantitative and qualitative measures of emphysema, local histogram emphysema patterns, and destructive emphysema subtypes. The polygenic risk score was associated with a reduced lung growth pattern. Interpretation: A risk score comprised of genetic variants can identify a small subset of individuals at markedly increased risk for moderate-to-severe COPD, emphysema subtypes associated with cigarette smoking, and patterns of reduced lung growth. Funding: US National Institutes of Health, Wellcome Trust.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087427951&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleChronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohortsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/S2213-2600(20)30101-6en_US
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087427951&origin=inwarden_US
Appears in Collections:Scopus 2020

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.