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Title: Prevalence of high-risk nonavalent vaccine-type human papillomavirus infection among unvaccinated, sexually active asian female adolescents with and without perinatally acquired HIV infection
Authors: Sirintip Sricharoenchai
Stephen J. Kerr
Stephen J. Kerr
Sivaporn Gatechompol
Rawiwan Hansudewechakul
Hanh Le Dung Dang
Dan Ngoc Hanh Tran
Nipat Teeratakulpisarn
Amphan Chalermchockcharoenkit
Jullapong Achalapong
Sirinya Teeraananchai
Thida Singtoroj
Nittaya Phanuphak
Annette H. Sohn
Kulkanya Chokephaibulkit
Thai Red Cross Agency
Chulalongkorn University
Kasetsart University
The HIV Netherlands Australia Thailand Research Collaboration
Faculty of Medicine, Siriraj Hospital, Mahidol University
Children's Hospital 1
Foundation for AIDS Research
Chiangrai Prachanukroh Hospital
Hung Vuong Hospital
Keywords: Medicine
Issue Date: 1-Jan-2020
Citation: Pediatric Infectious Disease Journal. (2020), 615-619
Abstract: © 2020 Wolters Kluwer Health, Inc. All rights reserved. Background: We studied the prevalence of 7, high-risk human papillomavirus (HPV) types in the nonavalent vaccine (HRVT-7: HPV 16, 18, 31, 33, 45, 52, 58) among vaccine-naïve, sexually active Asian female adolescents with and without perinatally acquired HIV infection (PHIV). Methods: PHIV female adolescents 12-24 years of age and HIV-uninfected controls matched by age and number of lifetime sex partners were enrolled in a 3-year observational cohort study in Thailand and Vietnam. Samples from the oral cavity, anus, cervix and vagina were collected for HRVT-7 HPV genotyping, and serum collected for HPV 16 and 18 antibody testing. Baseline data were analyzed using multivariable logistic regression. Results: We included 93 PHIV (median CD4 593 cells/mm3, 62% with HIV RNA suppression) and 99 HIV-uninfected adolescents (median lifetime sex partners 2). The overall prevalence of HRVT-7 infection was 53% in PHIV and 49% in HIV-uninfected adolescents (P = 0.66). Cervical HRVT-7 DNA was detected more frequently in PHIV than HIV-uninfected adolescents (37% vs. 23%, P = 0.04). Overall, more lifetime partners [≥3 vs. 1; odds ratio (OR) 2.99 (1.38-6.51), P = 0.02] and having other sexually transmitted infections [OR 3.30 (1.51-7.21), P = 0.003] increased the risk of HRVT-7 infection and/or positive HPV 16/18 antibodies; while detectable HIV RNA [OR 2.78 (1.05-7.36), P = 0.04] increased the risk among PHIV adolescents. Conclusions: Half of sexually active Asian female adolescents, regardless of HIV infection, had already acquired HRVT-7 infection. This underscores the need for earlier access to HPV vaccine in the region.
ISSN: 15320987
Appears in Collections:Scopus 2020

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