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Title: Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE
Authors: Jeffrey I. Weitz
Sylvia Haas
Walter Ageno
Samuel Z. Goldhaber
Alexander G.G. Turpie
Shinya Goto
Pantep Angchaisuksiri
Jørn Dalsgaard Nielsen
Gloria Kayani
Alfredo E. Farjat
Sebastian Schellong
Henri Bounameaux
Lorenzo G. Mantovani
Paolo Prandoni
Ajay K. Kakkar
Ab Loualidi
Abdurrahim Colak
Abraham Bezuidenhout
Abu Abdool-Carrim
Addala Azeddine
Adriaan Beyers
Adriaan Dees
Ahmed Mohamed
Ahmet Aksoy
Akihiko Abiko
Akinori Watanabe
Alan Krichell
Alberto Alfredo Fernandez
Alberto Tosetto
Alexey Khotuntsov
Alisha Oropallo
Alison Slocombe
Allan Kelly
Amanda Clark
Amr Gad
Amy Arouni
Andor Schmidt
Andrea Berni
Andres Javier Kleiban
Andrew Machowski
Andrey Kazakov
Angel Galvez
Ann Lockman
Anna Falanga
Anoop Chauhan
Antoni Riera-Mestre
Antonino Mazzone
Armando D’Angelo
Artur Herdy
Atsushi Kato
Ayman Abd Elhamid Ebrahim Mahmoud Salem
Azlan Husin
Barbara Erdelyi
Barry Jacobson
Beatrice Amann-Vesti
Bektas Battaloglu
Benedicte Wilson
Benilde Cosmi
Bergmann Jean Francois
Berremeli Toufek
Beverley Hunt
Bhavesh Natha
Bisher Mustafa
Bonnie Chi Shan Kho
Boulon Carine
Brian Zidel
Brisot Dominique
Brousse Christophe
Bruno Trimarco
Canhua Luo
Carlos Alberto Cuneo
Carlos Jerjes Sanchez Diaz
Carsten Schwencke
Cas Cader
Celal Yavuz
Cesar Javier Zaidman
Charles Lunn
Chau Chung Wu
Cheng Hock Toh
Chern En Chiang
Chevrier Elisa
Chien Hsun Hsia
Chien Lung Huang
Chi Hang Kevin Kwok
Chih Cheng Wu
Chi Hung Huang
Chris Ward
Christian Opitz
Christina Jeanneret-Gris
Chung Yin Ha
Chun Yao Huang
Claude Luyeye Bidi
Clifford Smith
Cornelia Brauer
Corrado Lodigiani
Couturaud Francis
Cynthia Wu
Daniel Staub
Daniel Theodoro
Daniela Poli
Thrombosis & Atherosclerosis Research Institute
IRCCS Multimedica
McMaster University
Tokai University School of Medicine
University College London
Technical University of Munich
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Copenhagen University Hospital
Thrombosis Research Institute
University of Milano - Bicocca
Hôpitaux universitaires de Genève
Università degli Studi dell'Insubria
Harvard Medical School
Municipal Hospital Dresden
Arianna Foundation on Anticoagulation
Keywords: Medicine
Issue Date: 1-Jan-2020
Citation: Journal of Thrombosis and Thrombolysis. (2020)
Abstract: © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Venous thromboembolism (VTE) is common in cancer patients and is an important cause of morbidity and mortality. The Global Anticoagulant Registry in the FIELD (GARFIELD)–VTE ( NCT02155491) is a prospective, observational study of 10,684 patients with objectively diagnosed VTE from 415 sites in 28 countries. We compared baseline characteristics, VTE treatment patterns, and 1-year outcomes (mortality, recurrent VTE and major bleeding) in 1075 patients with active cancer, 674 patients with a history of cancer, and 8935 patients without cancer. Patients with active cancer and history of cancer were older than cancer-free patients, with median ages of 64.8, 68.9, and 58.4 years, respectively. The most common sites of active cancer were lung (14.5%), colorectal (11.0%), breast (10.6%), and gynaecological (10.3%). Active cancer patients had a higher incidence of upper limb and vena cava thrombosis than cancer-free patients (9.0% vs 4.8% and 5.1% vs 1.4%, respectively), and were more likely to receive parenteral anticoagulation as monotherapy than cancer-free patients (57.8% vs 12.1%), and less likely to receive DOACs (14.2% vs 50.6%). Rates of death, recurrent VTE, and major bleeding were higher in active cancer patients than in cancer-free patients, with hazard ratios (95% confidence intervals) of 14.2 (12.1–16.6), 1.6 (1.2–2.0) and 3.8 (2.9–5.0), respectively. VTE was the second most common cause of death in patients with active cancer or history of cancer. In patients with VTE, those with active cancer are at higher risk of death, recurrence, and major bleeding than those without cancer.
ISSN: 1573742X
Appears in Collections:Scopus 2020

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