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|Title:||Expression profile of selected genes of the E-11 cell line in response to red-spotted grouper nervous necrosis virus infection|
Timothy J. Mahony
Duncan R. Smith
The University of Queensland
|Keywords:||Agricultural and Biological Sciences|
|Citation:||Aquaculture Reports. Vol.18, (2020)|
|Abstract:||© 2020 The Author(s) Most fish species are susceptible to red-spotted grouper nervous necrosis virus (RGNNV) which causes viral encephalopathy and retinopathy leading to huge financial losses in the aquaculture farming industry for decades. A knowledge of RGNNV replication and the host response in depth is warranted to understand the host-virus interaction and to develop an effective approach to inhibit this virus. This study therefore aimed to investigate the expression of selected immune and stress-related genes of the E-11 clonal cell line upon RGNNV infection. The results showed significant upregulation of viperin, hsp70 and tnfaip3 transcripts at 48 h post infection, while the transcript abundance of irf3, cc chemokine, hsp30 showed increases which did not reach significance and tnf-α showed no change in expression in response to infection. This study highlights the involvement of viperin, hsp70 and tnfaip3 during RGNNV infection of E-11 cells which provides a clearer understanding of the pathogenic mechanism of the disease.|
|Appears in Collections:||Scopus 2020|
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