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dc.contributor.authorKitipong Angsujindaen_US
dc.contributor.authorTimothy J. Mahonyen_US
dc.contributor.authorDuncan R. Smithen_US
dc.contributor.authorJes Kettrataden_US
dc.contributor.authorWanchai Assavalapsakulen_US
dc.contributor.otherThe University of Queenslanden_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationAquaculture Reports. Vol.18, (2020)en_US
dc.description.abstract© 2020 The Author(s) Most fish species are susceptible to red-spotted grouper nervous necrosis virus (RGNNV) which causes viral encephalopathy and retinopathy leading to huge financial losses in the aquaculture farming industry for decades. A knowledge of RGNNV replication and the host response in depth is warranted to understand the host-virus interaction and to develop an effective approach to inhibit this virus. This study therefore aimed to investigate the expression of selected immune and stress-related genes of the E-11 clonal cell line upon RGNNV infection. The results showed significant upregulation of viperin, hsp70 and tnfaip3 transcripts at 48 h post infection, while the transcript abundance of irf3, cc chemokine, hsp30 showed increases which did not reach significance and tnf-α showed no change in expression in response to infection. This study highlights the involvement of viperin, hsp70 and tnfaip3 during RGNNV infection of E-11 cells which provides a clearer understanding of the pathogenic mechanism of the disease.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleExpression profile of selected genes of the E-11 cell line in response to red-spotted grouper nervous necrosis virus infectionen_US
Appears in Collections:Scopus 2020

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