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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/59038
Title: ProIn-Fuse: improved and robust prediction of proinflammatory peptides by fusing of multiple feature representations
Authors: Mst Shamima Khatun
Md Mehedi Hasan
Watshara Shoombuatong
Hiroyuki Kurata
Kyushu Institute of Technology
Japan Society for the Promotion of Science
Mahidol University
Keywords: Chemistry;Computer Science
Issue Date: 1-Jan-2020
Citation: Journal of Computer-Aided Molecular Design. (2020)
Abstract: © 2020, Springer Nature Switzerland AG. A proinflammatory peptide (PIP) is a type of signaling molecules that are secreted from immune cells, which contributes to the first line of defense against invading pathogens. Numerous experiments have shown that PIPs play an important role in human physiology such as vaccines and immunotherapeutic drugs. Considering high-throughput laboratory methods that are time consuming and costly, effective computational methods are great demand to timely and accurately identify PIPs. Thus, in this study, we proposed a computational model in conjunction with a multiple feature representation, called ProIn-Fuse, to improve the performance of PIPs identification. Specifically, a feature representation learning model was utilized to generate the probabilistic scores by using the random forest models employing eight sequence encoding schemes. Finally, the ProIn-Fuse was constructed by linearly combining the resultant eight probabilistic scores. Evaluated through independent test, the ProIn-Fuse yielded an accuracy of 0.746, which was 10% higher than those obtained by the state-of-the-art PIP predictors. The proposed ProIn-Fuse can facilitate faster and broader applications of PIPs in drug design and development. The web server, datasets and online instruction are freely accessible at http://kurata14.bio.kyutech.ac.jp/ProIn-Fuse.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/59038
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85091282929&origin=inward
ISSN: 15734951
0920654X
Appears in Collections:Scopus 2020

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