Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Risk factors associated with large clusters of tuberculosis patients determined by whole-genome sequencing in a high-tuberculosis-burden country
Authors: Reiko Miyahara
Nat Smittipat
Tada Juthayothin
Hideki Yanai
Areeya Disratthakit
Worarat Imsanguan
Daranee Intralawan
Supalert Nedsuwan
Boonchai Chaiyasirinroje
Surasit Bupachat
Katsushi Tokunaga
Surakameth Mahasirimongkol
Prasit Palittapongarnpim
The University of Tokyo
National Center for Global Health and Medicine
Thailand Ministry of Public Health
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
TB-HIV Research Foundation
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2020
Citation: Tuberculosis. Vol.125, (2020)
Abstract: © 2020 Elsevier Ltd Whole-genome sequencing (WGS) analysis has great discriminative power for detecting similar molecular fingerprints of suspected tuberculosis (TB) clusters. The proportion of TB cases within clusters and the associated risk factors are important epidemiological parameters guiding appropriate outbreak control strategies in endemic settings. We conducted a hospital-based TB case-cohort study between 2003 and 2011 in the northernmost province of Thailand. We identified TB clusters by Mycobacterium tuberculosis WGS and analysed the risks of TB clustering and the characteristics of large clusters compared with small clusters. Among 1146 TB isolates, we identified 77 clusters with 251 isolates defined by a 5-single-nucleotide variant (SNV) cutoff and 112 clusters with 431 isolates defined by a 12-SNV cutoff. Twelve large clusters with 6 isolates or more in each cluster were identified by a 12-SNV cutoff. Sublineage 2.2.1 (both Ancestral and Modern) strains and imprisonment were independently associated with large clusters. Furthermore, although large clusters of Lineage 2.2.1/Ancestral strains included a high number of prisoners, Lineage 2.2.1/Modern strain clusters were only associated with treatment failures and drug resistance. Heterogeneity among lineage strains was observed with respect to large-cluster characteristics. Patients with an increased TB-transmission tendency should be priority targets for contact investigations and outbreak interventions to prevent ongoing transmission.
ISSN: 1873281X
Appears in Collections:Scopus 2020

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.