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Title: Epstein-barr virus mediated signaling in nasopharyngeal carcinoma carcinogenesis
Authors: Timmy Richardo
Pongphol Prattapong
Chawalit Ngernsombat
Nurulfitri Wisetyaningsih
Hisashi Iizasa
Hironori Yoshiyama
Tavan Janvilisri
Shimane University
Medizinische Hochschule Hannover (MHH)
Mahidol University
Indonesia International Institute for Life Sciences
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Sep-2020
Citation: Cancers. Vol.12, No.9 (2020), 1-23
Abstract: © MDPI AG. All rights reserved. Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which is Epstein-Barr virus (EBV) infection. Although evidence demonstrates that EBV infection plays a key role in NPC carcinogenesis, the exact relationship between EBV and dysregulation of signaling pathways in NPC needs to be clarified. This review focuses on the interplay between EBV and NPC cells and the corresponding signaling pathways, which are modulated by EBV oncoproteins and non-coding RNAs. These altered signaling pathways could be critical for the initiation and progression of NPC.
ISSN: 20726694
Appears in Collections:Scopus 2020

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