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Title: Risk factors of leishmania infection among hiv-infected patients in trang province, southern Thailand: A study on three prevalent species
Authors: Sakarn Charoensakulchai
Lertwut Bualert
Jipada Manomat
Mathirut Mungthin
Saovanee Leelayoova
Peerapan Tan-Ariya
Suradej Siripattanapipong
Tawee Naaglor
Phunlerd Piyaraj
Trang Hospital
Mahidol University
Phramongkutklao College of Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2020
Citation: American Journal of Tropical Medicine and Hygiene. Vol.103, No.4 (2020), 1502-1509
Abstract: Copyright © 2020 by The American Society of Tropical Medicine and Hygiene There are two main species of Leishmania reported in Thailand, that is, Leishmania siamensis and Leishmania martiniquensis. Moreover, leishmaniasis cases caused by Leishmania donovani complex were also reported. There is still a lack of information concerning risk factors of Leishmania infection in Thailand. This study aimed to identify the risk factors of Leishmania infection caused by these three species among HIV-infected patients. A cross-sectional study was conducted in HIV clinic at Trang Hospital, Thailand. Nested PCR and sequencing were performed to detect Leishmania DNA in blood and saliva samples and identify Leishmania species. A standardized questionnaire was used to interview individuals. A total of 526 patients were recruited in this study. Sixty-three (12.0%) were positive for L. siamensis, 24 (4.6%) were positive for L. martiniquensis, and 23 (4.4%) were positive for L. donovani complex. Risk factors of L. siamensis infection included using intravenous drug (adjusted odds ratio [AOR] 2.01, 95% CI: 1.01-4.02). Risk factors of L. martiniquensis infection included female gender (AOR 4.23, 95% CI: 1.52-11.75), using recreational drug (AOR 3.43, 95% CI: 1.00-11.74), and having comorbidities (AOR 4.94, 95% CI: 2.00-12.21). Risk factors of L. donovani complex infection included having opportunistic infection (AOR 4.22, 95% CI: 1.00-17.79), CD4 count 200-500 cells/mm3 (AOR 3.64, 95% CI: 1.14-6.86), and not using insect repellent (AOR 3.04, 95% CI: 1.08-8.58). This study identified the risk factors of Leishmania infection caused by three Leishmania species in Thailand. The data could be useful for disease prevention and control. Further studies on trends of Leishmania infection and preventive measures are recommended.
ISSN: 14761645
Appears in Collections:Scopus 2020

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