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Title: Interepidemic detection of chikungunya virus infection and transmission in Northeastern Thailand
Authors: Bao Chi Thi Le
Tipaya Ekalaksananan
Kesorn Thaewnongiew
Supranee Phanthanawiboon
Sirinart Aromseree
Thipruethai Phanitchat
Jureeporn Chuerduangphui
Apiporn T. Suwannatrai
Neal Alexander
Hans J. Overgaard
Michael J. Bangs
Chamsai Pientong
University Medicine and Pharmacy, Hue University
PT Freeport Indonesia
London School of Hygiene & Tropical Medicine
Kasetsart University
Khon Kaen University
Mahidol University
Universitetet for miljø- og biovitenskap
Region 7 Khon Kaen Ministry of Public Health
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2020
Citation: American Journal of Tropical Medicine and Hygiene. Vol.103, No.4 (2020), 1660-1669
Abstract: Copyright © 2020 by The American Society of Tropical Medicine and Hygiene Chikungunya fever is a viral mosquito-borne, acute febrile illness associated with rash, joint pain, and occasionally prolonged polyarthritis. Chikungunya outbreaks have been reported worldwide including many provinces of Thailand. Although chikungunya virus (CHIKV) occurs in Thailand, details on its epidemiology are lacking compared with dengue, a common mosquito-borne disease in the country. Therefore, study on CHIKV and its epidemiology in both humans and mosquitoes is required to better understand its importance clinically and dynamics in community settings. So a prospective examination of virus circulation in human and mosquito populations in northeastern Thailand using serological and molecular methods, including the genetic characterization of the virus, was undertaken. The study was conducted among febrile patients in eight district hospitals in northeastern Thailand from June 2016 to October 2017. Using real-time PCR on the conserved region of nonstructural protein 1 gene, CHIKV was detected in eight (4.9%) of 161 plasma samples. Only one strain yielded a sequence of sufficient size allowing for phylogenetic analysis. In addition, anti-CHIKV IgM and IgG were detected in six (3.7%) and 17 (10.6%) patient plasma samples. The single sequenced sample belonged to the East/Central/South Africa (ECSA) genotype and was phylogenetically similar to the Indian Ocean sub-lineage. Adult Aedes mosquitoes were collected indoors and within a 100-m radius from the index case house and four neighboring houses. CHIKV was detected in two of 70 (2.9%) female Aedes aegypti mosquito pools. This study clearly demonstrated the presence and local transmission of the ECSA genotype of CHIKV in the northeastern region of Thailand.
ISSN: 14761645
Appears in Collections:Scopus 2020

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