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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/60030
Title: Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study
Authors: Nittaya Phanuphak
Sirinya Teeraananchai
Rawiwan Hansudewechakul
Sivaporn Gatechompol
Kulkanya Chokephaibulkit
Hanh Le Dung Dang
Dan Ngoc Hanh Tran
Jullapong Achalapong
Nipat Teeratakulpisarn
Amphan Chalermchockcharoenkit
Manopchai Thamkhantho
Tippawan Pankam
Thida Singtoroj
Wichai Termrungruanglert
Surasith Chaithongwongwatthana
Stephen J. Kerr
Annette H. Sohn
Thai Red Cross Agency
Chulalongkorn University
Kirby Institute
Kasetsart University
The HIV Netherlands Australia Thailand Research Collaboration
Faculty of Medicine, Siriraj Hospital, Mahidol University
Children's Hospital 1
TREAT Asia/amfAR-The Foundation for AIDS Research
Chiangrai Prachanukroh Hospital
Hung Vuong Hospital
Keywords: Medicine
Issue Date: 5-Nov-2020
Citation: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Vol.71, No.8 (2020), e270-e280
Abstract: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: Female youth with perinatally acquired human immunodeficiency virus (PHIV) may be at higher risk than uninfected youth for persistent anogenital human papillomavirus (HPV) infection, due to prolonged immunodeficiency. METHODS: A 3-year cohort study was conducted between 2013 and 2017 among Thai and Vietnamese PHIV and HIV-uninfected females 12-24 years, matched by age group and number of lifetime sexual partners. For HPV genotyping, cervical and anal samples were obtained at baseline and annually. Vaginal samples were collected at baseline and every 6 months. Factors associated with high-risk HPV (HR-HPV) persistence and incidence were assessed. RESULTS: We enrolled 93 PHIV and 99 HIV-uninfected females. Median age was 19 (interquartile range [IQR] 18-20) years. For the 7 HR-HPV types (16, 18, 31, 33, 45, 52, 58) in the nonavalent HPV vaccine, PHIV had significantly higher incidence (P = .03) and persistence (P = .01) than HIV-uninfected youth over a 3-year period. Having HIV (adjusted hazard ratio [aHR] 2.1, 95% confidence interval [CI] 1.1-3.9) and ever using illegal substances (aHR 4.8, 95% CI 1.8-13.0) were associated with incident 7 HR-HPV infections. HIV-positive status (adjusted prevalence ratio [aPR] 2.2, 95% CI 1.5-3.2), recent alcohol use (aPR 1.75, 95% CI 1.2-2.5), and higher number of lifetime partners (aPR 2.0, 95% CI 1.4-3.1, for 3-5 partners; aPR 1.93, 95% CI 1.2-3.2, for ≥6 partners) were significantly associated with persistent 7 HR-HPV infections. CONCLUSIONS: Female PHIV were at higher risk of having anogenital HR-HPV acquisition and persistence. Primary and secondary prevention programs for HPV infection and HPV-related diseases should be prioritized for PHIV children and youth.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/60030
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095861725&origin=inward
ISSN: 15376591
Appears in Collections:Scopus 2020

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