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Title: Etiologies of acute optic neuritis in thailand: An observational study of 171 patients
Authors: Kavin Vanikieti
Pavarut Janyaprasert
Sirin Lueangram
Jirat Nimworaphan
Natthapon Rattanathamsakul
Nanida Tiraset
Wimonwan Chokthaweesak
Narong Samipak
Tanyatuth Padungkiatsagul
Pisit Preechawat
Anuchit Poonyathalang
Teeratorn Pulkes
Supoch Tunlayadechanont
Sukanya Siriyotha
Panitha Jindahra
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2020
Citation: Clinical Ophthalmology. Vol.14, (2020), 2935-2942
Abstract: © 2020 Vanikieti et al. Purpose: To analyze the demographic patterns, clinical characteristics and etiologies of acute optic neuritis (ON). Methods: This retrospective observational study included patients with acute ON who presented to a university hospital in Bangkok, Thailand, between January 2010 and March 2020. The demographic details, clinical characteristics and etiologies of acute ON were evaluated. Results: A total of 171 patients were included in the study (78.4% [n=134] female; mean age 45 years [standard deviation 15.4 years]; 32.2% [n=55] bilateral involvement). The most common type of acute ON was idiopathic (51.5%), followed by neuromyelitis optica spectrum disorder (NMOSD, 30.9%), other autoimmune disorders (9.9%), myelin oligoden-drocyte glycoprotein antibody-associated disorder (MOGAD, 5.3%), multiple sclerosis (MS, 1.8%), and postinfection (0.6%). In the other autoimmune disorders group, 2 patients developed systemic lupus erythematosus (1.2%), 2 Sjogren’s syndrome (1.2%), 1 RA (0.6%), 1 anti-NMDAR (0.6%), 3 anti-Jo1 (1.8%), 2 c-ANCA (1.2%), 1 anti-centromere (0.6%), and 5 nonspecific autoimmune disorders (2.9%). In the idiopathic group, 38.6% developed single isolated ON, 1.8% relapsing isolated ON and 11.1% chronic relapsing inflammatory optic neuropathy. Conclusion: The most common form of acute ON in this study, similar to other Asian countries, was idiopathic. Idiopathic-ON shared some phenotypes with NMOSD and MOGAD. We also reported patients with anti-NMDAR, anti-Jo1, c-ANCA and anti-centro-mere disorders. Improvements in antibody detection have widened the range of possible etiologies of acute ON. The study highlighted the important role of antibodies in creating effective treatments in the future.
ISSN: 11775483
Appears in Collections:Scopus 2020

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