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Title: Incidence, Persistence, and Factors Associated With HPV Infection Among Male Adolescents With and Without Perinatally Acquired HIV Infection
Authors: Sivaporn Gatechompol
Nipat Teeratakulpisarn
Orasri Wittawatmongkol
Sirinya Teeraananchai
Stephen J. Kerr
Amphan Chalermchockcharoenkit
Manopchai Thamkhantho
Thida Singtoroj
Nittaya Phanuphak
Annette H. Sohn
Kulkanya Chokephaibulkit
Thai Red Cross Agency
Chulalongkorn University
Kasetsart University
The HIV Netherlands Australia Thailand Research Collaboration
Faculty of Medicine, Siriraj Hospital, Mahidol University
TREAT Asia/amfAR-The Foundation for AIDS Research
Keywords: Medicine
Issue Date: 15-Dec-2020
Citation: Journal of acquired immune deficiency syndromes (1999). Vol.85, No.5 (2020), 553-560
Abstract: BACKGROUND: Infection with high-risk human papillomavirus (HR-HPV) has been shown to be more prevalent and persistent in female adolescents with HIV. However, data among male adolescents with perinatally acquired HIV (PHIV) are limited. SETTING: We investigated the incidence and persistence of HR-HPV in anogenital compartments and associated factors among PHIV in comparison to HIV-uninfected (HU) male adolescents in Thailand. METHODS: PHIV and HU males aged 12-24 years were enrolled. At baseline and 3 subsequent annual visits, specimens from the scrotum, penis, and anal area were obtained for HPV and other testing. RESULTS: From June 2013 to October 2017, 49 PHIV and 47 HU male adolescents with a median age of 18 (interquartile range 17-20) years were enrolled. PHIV had higher incidence of any HR-HPV infection than HU adolescents {33.05 [95% confidence interval (CI): 20.82 to 52.46] vs. 15.73 [95% CI: 8.18 to 30.22] per 100 person-years, P = 0.04}. The persistence of any HR-HPV genotypes (detected at ≥2 annual visits) was not different by group (PHIV 27% vs. HU 23%, P = 0.75). Having ≥3 sex partners in past 6 months (adjusted prevalence ratio 2.39, 95% CI: 1.14 to 5.05; P = 0.02) and co-infection with other sexually transmitted infections (syphilis, chlamydia, and/or gonorrhea) were associated with persistent HR-HPV infection (adjusted prevalence ratio 6.21, 95% CI: 2.87 to 13.41; P < 0.001). CONCLUSIONS: Thai PHIV male adolescents had a higher incidence of HR-HPV infection than those without HIV. Having multiple sex partners and co-infection with sexually transmitted infections was associated with persistent HR-HPV infection. These data demonstrate the need to prioritize PHIV male adolescents in routine and catch-up HPV vaccination programs.
ISSN: 19447884
Appears in Collections:Scopus 2020

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