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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/61197
Title: Tafenoquine: a toxicity overview
Authors: Cindy S. Chu
Jimee Hwang
Shoklo Malaria Research Unit
University of California, San Francisco
Centers for Disease Control and Prevention
Nuffield Department of Medicine
Keywords: Medicine
Issue Date: 1-Jan-2021
Citation: Expert Opinion on Drug Safety. (2021)
Abstract: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Introduction: A century-long history in 8-aminoquinolines, the only anti-malaria drug class preventing malaria relapse, has resulted in the approval of tafenoquine by the U.S. Food and Drug Administration (FDA) and the Australian Therapeutic Goods Administration (TGA) and to date registration in Brazil and Thailand. Tafenoquine is an alternative anti-relapse treatment for vivax malaria and malaria prophylaxis. It should not be given in pregnancy, during lactation of infants with glucose-6-phosphate dehydrogenase (G6PD) unknown or deficient status, and in those with G6PD deficiency or psychiatric illness. Areas covered: This systematic review assesses tafenoquine associated adverse events in English-language, human clinical trials. Meta-analysis of commonly reported adverse events was conducted and grouped by comparison arms.Expert opinion: Tafenoquine, either for radical cure or prophylaxis, is generally well tolerated in adults. There is no convincing evidence for neurologic, ophthalmic, and cardiac toxicities. Psychotic disorder which has been attributed to higher doses is a contraindication for the chemoprophylaxis indication and psychiatric illness is a warning for the radical cure indication. Pregnancy assessment and quantitative G6PD testing are required. The optimal radical curative regimen including the tafenoquine dose along with its safety for parts of Southeast Asia, South America, and Oceania needs further assessment.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/61197
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85098617274&origin=inward
ISSN: 1744764X
14740338
Appears in Collections:Scopus 2021

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