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|Title:||Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5|
Ivy Grace Umadhay Pait
Toyama Prefectural University
|Keywords:||Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Antibiotics. (2021)|
|Abstract:||© 2021, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. In our screening program for new biologically active compounds, a new polyene macrolide, lavencidin (1), along with known compound RKGS-A2215A (2), was isolated from the fermentation broth of Streptomyces lavendulae FRI-5 by changing the composition of liquid medium normally used for the strain. Their structures were elucidated by spectral methods (high-resolution fast-atom bombardment mass spectrometry (HRFABMS) and nuclear magnetic resonance (NMR)). Compound 1 includes a conjugated pentaene moiety together with six hydroxy groups and a carboxylic acid as a side chain. Lavencidin (1) showed moderate growth-inhibitory activity against yeast and was cytotoxic against human cancer cell lines with low-micromolar IC50 values.|
|Appears in Collections:||Scopus 2021|
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