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Title: Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5
Authors: Takuya Yoshioka
Yasuhiro Igarashi
Takushi Namba
Shohei Ueda
Ivy Grace Umadhay Pait
Takuya Nihira
Shigeru Kitani
Toyama Prefectural University
Osaka University
Kochi University
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2021
Citation: Journal of Antibiotics. (2021)
Abstract: © 2021, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. In our screening program for new biologically active compounds, a new polyene macrolide, lavencidin (1), along with known compound RKGS-A2215A (2), was isolated from the fermentation broth of Streptomyces lavendulae FRI-5 by changing the composition of liquid medium normally used for the strain. Their structures were elucidated by spectral methods (high-resolution fast-atom bombardment mass spectrometry (HRFABMS) and nuclear magnetic resonance (NMR)). Compound 1 includes a conjugated pentaene moiety together with six hydroxy groups and a carboxylic acid as a side chain. Lavencidin (1) showed moderate growth-inhibitory activity against yeast and was cytotoxic against human cancer cell lines with low-micromolar IC50 values.
ISSN: 18811469
Appears in Collections:Scopus 2021

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