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dc.contributor.authorTakuya Yoshiokaen_US
dc.contributor.authorYasuhiro Igarashien_US
dc.contributor.authorTakushi Nambaen_US
dc.contributor.authorShohei Uedaen_US
dc.contributor.authorIvy Grace Umadhay Paiten_US
dc.contributor.authorTakuya Nihiraen_US
dc.contributor.authorShigeru Kitanien_US
dc.contributor.otherToyama Prefectural Universityen_US
dc.contributor.otherOsaka Universityen_US
dc.contributor.otherKochi Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationJournal of Antibiotics. (2021)en_US
dc.description.abstract© 2021, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. In our screening program for new biologically active compounds, a new polyene macrolide, lavencidin (1), along with known compound RKGS-A2215A (2), was isolated from the fermentation broth of Streptomyces lavendulae FRI-5 by changing the composition of liquid medium normally used for the strain. Their structures were elucidated by spectral methods (high-resolution fast-atom bombardment mass spectrometry (HRFABMS) and nuclear magnetic resonance (NMR)). Compound 1 includes a conjugated pentaene moiety together with six hydroxy groups and a carboxylic acid as a side chain. Lavencidin (1) showed moderate growth-inhibitory activity against yeast and was cytotoxic against human cancer cell lines with low-micromolar IC50 values.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleLavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5en_US
Appears in Collections:Scopus 2021

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