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Title: Clusters of drug-resistant mycobacterium tuberculosis detected by whole-genome sequence analysis of nationwide sample, Thailand, 2014–2017
Authors: Ditthawat Nonghanphithak
Angkana Chaiprasert
Saijai Smithtikarn
Phalin Kamolwat
Petchawan Pungrassami
Virasakdi Chongsuvivatwong
Surakameth Mahasirimongkol
Wipa Reechaipichitkul
Chaniya Leepiyasakulchai
Jody E. Phelan
David Blair
Taane G. Clark
Kiatichai Faksri
London School of Hygiene & Tropical Medicine
James Cook University
Khon Kaen University
Thailand Ministry of Public Health
Mahidol University
Prince of Songkla University
Keywords: Medicine
Issue Date: 1-Mar-2021
Citation: Emerging Infectious Diseases. Vol.27, No.3 (2021), 813-822
Abstract: © 2021 Centers for Disease Control and Prevention (CDC). All rights reserved. Multidrug-resistant tuberculosis (MDR TB), pre-extensively drug-resistant tuberculosis (pre-XDR TB), and extensively drug-resistant tuberculosis (XDR TB) complicate disease control. We analyzed whole-genome sequence data for 579 phenotypically drug-resistant M. tuberculosis isolates (28% of available MDR/pre-XDR and all culturable XDR TB isolates collected in Thailand during 2014–2017). Most isolates were from lineage 2 (n = 482; 83.2%). Cluster analysis revealed that 281/579 isolates (48.5%) formed 89 clusters, including 205 MDR TB, 46 pre-XDR TB, 19 XDR TB, and 11 poly–drug-resistant TB isolates based on genotypic drug resistance. Members of most clusters had the same subset of drug resistance-associated mutations, supporting potential primary resistance in MDR TB (n = 176/205; 85.9%), pre-XDR TB (n = 29/46; 63.0%), and XDR TB (n = 14/19; 73.7%). Thirteen major clades were significantly associated with geography (p<0.001). Clusters of clonal origin contribute greatly to the high prevalence of drug-resistant TB in Thailand.
ISSN: 10806059
Appears in Collections:Scopus 2021

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