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Title: Chemical stability and mechanism of degradation of omeprazole in solution
Other Titles: ความคงตัวทางเคมีและกลไกการเสื่อมสลายของโอมิปราโซลในสารละลาย
Authors: Narong Sarisuta
Tudsong Tourtip
Siripote Chuarcharoern
ณรงค์ สาริสุต
ทัดทรง ทั่วทิพย์
ศิริพจน์ เชื้อเจริญ
Mahidol University. Faculty of Pharmacy. Department of Manufacturing Pharmacy
Keywords: Omeprazole;Drug Stability;Chemical kinetics;Mechanism of degradation
Issue Date: 1998
Citation: Thai Journal of Pharmaceutical Sciences. Vol. 22, No. 2 (1998), 81-88.
Abstract: The chemical stability and kinetics of omeprazole in buffer solutions at various pH values, 5.0, 8.0, and 10.0 were studied at three different stress conditions, 25, 40, and 50 C. It was found that the degradtion reaction followed the pseudo first-order kinetics and was quite rapid at low pH values with a half-life of 43 min at pH 5.0 and 25 C. In alkaline pH of 10.0 the drug was however remarkbly stable with a half-life of 2.8 months at 25 C. The energy of activation was pH-dependent and varied from 9.9-19.6 kcal/mol. The pH-log rate profiles in association with other thermodynamic activation parameters suggested that the main pathway of degradation reaction would be the hydrolysis with depending on hydronium ion concentration involving bimolecular reaction.
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