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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/62713
Title: The influence of drug-excipient and drug-polymer interactions on butt adhesive strength of Ranitidine Hydrochloride film-coated tablets
Authors: Narong Sarisuta
Pojawon Lawanprasert
Satit Puttipipatkhachorn
ณรงค์ สาริสุต
พจวรรณ ลาวัณย์ประเสริฐ
สาธิต พุทธพิพัฒน์ขจร
Krisana Srikummoon
Mahidol University. Faculty of Pharmacy. Department of Manufacturing Pharmacy
Government Pharmaceutical Organization (Thailand). Production Division.
Narong Sarisuta (e-mail: pynst@mahidol.ac.th)
Keywords: Film-Coated Tablets;Drug-Excipient Interaction;Drug-Polymer Interaction;Adhesive Strength;Ranitidine HCI;Hydroxypropyl Methylcellulo;Eudragit E100
Issue Date: 2006
Citation: Drug Development and Industrial Pharmacy. Vol.32, (2006), 463-471.
Abstract: The influence of fillers and polymeric films on adhesive strength of hydroxypropyl methylcellulose (HPMC) and Eudragit E100® films coated on ranitidine HCl tablets containing either spray-dried rice starch (SDRS) or lactose monohydrate as fillers after storage at 45°C/75% RH for four weeks was investigated by the use of butt adhesion technique. The adhesive strength of film-coated tablets of fillers without drug was found to slightly decrease after storage. In contrast, the adhesive strength of drug-containing film-coated tablets significantly reduced, the degree of which was higher for Eudragit E100® than HPMC. Physicochemical characterization by employing differential scanning calorimetry (DSC) and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) revealed that the drug was obviously incompatible with lactose and possibly mild interaction with Eudragit E100® was suggested. The results indicated that the adhesive strength of film-coated tablets would be affected not only by the drug-excipient interaction, but also by the drug-polymeric film interaction.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/62713
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