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Title: Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
Authors: Rijken, Marcus J.
Boel, Machteld E.
Russell, Bruce
Mallika Imwong
มัลลิกา อิ่มวงศ์
Leimanis, Mara L.
Phyo, Aung Pyae
Muehlenbachs, Atis
Lindegardh, Niklas
McGready, Rose
Rénia, Laurent
Snounou, Georges
Pratap Singhasivanon
ประตาป สิงหศิวานนท์
Nosten, François
Mahidol University. Faculty of Tropical Medicine.Department of Molecular Tropical Medicine and Genetics
Rijken, Marcus J.
Keywords: Antimalarials;Chloroquine;DNA, protozoan;Drug resistance;Malaria, vivax;Plasmodium vivax;Pregnancy complications, infectious;Open Access article
Issue Date: 5-May-2011
Citation: Rijken MJ, Boel ME, Russell B, Imwong M, Leimanis ML, Phyo AP, et al. Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand. Malar J. 2011 May 5;10:113.
Abstract: Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.
ISSN: 1475-2875 (electronic)
Appears in Collections:TM-Article

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