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Title: SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Authors: Wanwisa Dejnirattisai
Jiandong Huo
Daming Zhou
Jiří Zahradník
Piyada Supasa
Chang Liu
Helen M.E. Duyvesteyn
Helen M. Ginn
Alexander J. Mentzer
Aekkachai Tuekprakhon
Rungtiwa Nutalai
Beibei Wang
Aiste Dijokaite
Suman Khan
Ori Avinoam
Mohammad Bahar
Donal Skelly
Sandra Adele
Sile Ann Johnson
Ali Amini
Thomas G. Ritter
Chris Mason
Christina Dold
Daniel Pan
Sara Assadi
Adam Bellass
Nicola Omo-Dare
David Koeckerling
Amy Flaxman
Daniel Jenkin
Parvinder K. Aley
Merryn Voysey
Sue Ann Costa Clemens
Felipe Gomes Naveca
Valdinete Nascimento
Fernanda Nascimento
Cristiano Fernandes da Costa
Paola Cristina Resende
Alex Pauvolid-Correa
Marilda M. Siqueira
Vicky Baillie
Natali Serafin
Gaurav Kwatra
Kelly Da Silva
Shabir A. Madhi
Marta C. Nunes
Tariq Malik
Peter J.M. Openshaw
J. Kenneth Baillie
Malcolm G. Semple
Alain R. Townsend
Kuan Ying A. Huang
Tiong Kit Tan
Miles W. Carroll
Paul Klenerman
Eleanor Barnes
Susanna J. Dunachie
Bede Constantinides
Hermione Webster
Derrick Crook
Andrew J. Pollard
Teresa Lambe
Christopher Conlon
Alexandra S. Deeks
John Frater
Lisa Frending
Siobhan Gardiner
Anni Jämsén
Katie Jeffery
Tom Malone
Eloise Phillips
Lucy Rothwell
Lizzie Stafford
J. Kenneth Baillie
Peter JM Openshaw
Gail Carson
Beatrice Alex
Petros Andrikopoulos
Benjamin Bach
Wendy S. Barclay
Debby Bogaert
Meera Chand
Kanta Chechi
Graham S. Cooke
Ana da Silva Filipe
Thushan de Silva
Annemarie B. Docherty
Gonçalo dos Santos Correia
Marc Emmanuel Dumas
Jake Dunning
Tom Fletcher
Christoper A. Green
William Greenhalf
Julian L. Griffin
Rishi K. Gupta
Ewen M. Harrison
Julian A. Hiscox
Antonia Ying Wai Ho
Peter W. Horby
Samreen Ijaz
Mahidol Oxford Tropical Medicine Research Unit
NIHR Oxford Biomedical Research Centre
Oxford University Hospitals NHS Foundation Trust
Texas A&M College of Veterinary Medicine & Biomedical Sciences
Public Health England
Diamond Light Source
University of the Witwatersrand Faculty of Health Sciences
Chang Gung University College of Medicine
University of Leicester
University Hospitals of Leicester NHS Trust
University of Oxford
University of Edinburgh, Roslin Institute
Fundacao Oswaldo Cruz
University of Liverpool
Fiocruz Amazônia
Weizmann Institute of Science Israel
School of Pathology
National Heart and Lung Institute
Nuffield Department of Medicine
Università degli Studi di Siena
University of Oxford Medical Sciences Division
Fundação de Vigilância em Saúde do Amazonas
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 3-Feb-2022
Citation: Cell. Vol.185, No.3 (2022), 467-484.e15
Abstract: On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.
ISSN: 10974172
Appears in Collections:Scopus 2022

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