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Title: Biomarker-Determined Nonylphenol Exposure and Associated Risks in Children of Thailand, Indonesia, and Saudi Arabia
Authors: Benedikt Ringbeck
Daniel Bury
Inae Lee
Gowoon Lee
Raid Alakeel
May Alrashed
Ramadhan Tosepu
Erwin Azizi Jayadipraja
Kraichat Tantrakarnapa
Wissanupong Kliengchuay
Thomas Brüning
Kyungho Choi
Holger M. Koch
Faculty of Tropical Medicine, Mahidol University
Universitas Halu Oleo
College of Applied Medical Sciences
Seoul National University
King Saud University
Ruhr-Universitat Bochum
Mandala Waluya University
Keywords: Chemistry;Environmental Science
Issue Date: 19-Jul-2022
Citation: Environmental science & technology. Vol.56, No.14 (2022), 10229-10238
Abstract: Nonylphenol (NP) is an endocrine disruptor and environmental contaminant. Yet, data on individual body burdens and potential health risks in humans, especially among children, are scarce. We analyzed two specific urinary NP metabolites, hydroxy-NP (OH-NP) and oxo-NP. In contrast to parent NP, OH-NP has a much higher urinary excretion fraction (Fue), and both are insusceptible to external contamination. We investigated spot urine samples from school children of Thailand (n = 104), Indonesia (n = 89), and Saudi Arabia (n = 108) and could quantify OH-NP in 100% of Indonesian and Saudi children (median concentrations: 8.12 and 8.57 μg/L) and in 76% of Thai children (1.07 μg/L). Median oxo-NP concentrations were 0.95, 1.10, and <0.25 μg/L, respectively, in line with its lower Fue. Median daily NP intakes (DIs), back-calculated from urinary OH-NP concentrations, were significantly higher in Indonesia and Saudi Arabia [0.47 and 0.36 μg/(kg bw·d), respectively] than in Thailand [0.06 μg/(kg bw·d)]. Maximum DIs were close to the preliminary tolerable DI of 5 μg/(kg bw·d) from the Danish Environmental Protection Agency. Dominant sources of exposure or relevant exposure pathways could not be readily identified by questionnaire analyses and also potentially varied by region. The novel biomarkers provide long-needed support to the quantitative exposure and risk assessment of NP.
ISSN: 15205851
Appears in Collections:Scopus 2022

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