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dc.contributor.authorSaranath Lawpoolsrien
dc.contributor.authorสารนาถ ล้อพูลศรีen
dc.contributor.authorChavez, Irwin F.en
dc.contributor.authorSurapon Yimsamranen
dc.contributor.authorสุรพล ยิ้มสำราญen
dc.contributor.authorSupalap Puangsa-arten
dc.contributor.authorสุภลาภ พวงสอาดen
dc.contributor.authorNipon Thanyavanichen
dc.contributor.authorนิพนธ์ ธัญญวานิชen
dc.contributor.authorWanchai Maneeboonyangen
dc.contributor.authorWuthichai Chaimungkunen
dc.contributor.authorPratap Singhasivanonen
dc.contributor.authorประตาป สิงหศิวานนท์en
dc.contributor.authorMaguire, James H.en
dc.contributor.authorHungerford, Laura L.en
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Department of Tropical Hygiene
dc.date.accessioned2010-11-17T07:22:37Zen
dc.date.accessioned2011-08-29T05:16:47Z
dc.date.accessioned2016-10-05T06:54:17Z-
dc.date.available2010-11-17T07:22:37Zen
dc.date.available2011-08-29T05:16:47Z
dc.date.available2016-10-05T06:54:17Z-
dc.date.copyright2010
dc.date.created2010-11-17en
dc.date.issued2010-05en
dc.identifier.citationLawpoolsri S, Chavez IF, Yimsamran S, Puangsa-Art S, Thanyavanich N, Maneeboonyang W, et al. The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border. Malar J 2010 May 26;9:143.
dc.identifier.issn1475-2875 (electronic)
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/755-
dc.description.abstractBACKGROUND: The probability of contracting malaria in a given individual is determined not only by the individual's characteristics, but also the ecological factors that characterize the level of human-vector contact in the population. Examination of the relationship between "individual" and "supra-individual" variables over time is important for understanding the local malaria epidemiology. This is essential for planning effective intervention strategies specifically for each location. METHODS: A retrospective cohort study was conducted, which followed a community-cohort of about 3,500 residents in seven hamlets along the Thai-Myanmar border between 1999 and 2006. Potential malaria determinants measured at different levels (temporal variables, individual variables, and hamlet variables) were incorporated into multilevel models to estimate their effects on an individual's risk of malaria attack. RESULTS: The monthly minimum temperature was significantly associated with the seasonal variation of malaria risk. An individual risk of malaria attack decreased by about 50% during the period that active surveillance was conducted; an additional 15% and 25% reduction of Plasmodium falciparum and Plasmodium vivax incidence, respectively, was observed after the use of artesunate-mefloquine combination therapy (ACT) for treatment of P. falciparum. Male children (age < 16 years old) were at highest risk of both P. falciparum and P. vivax attack. An increase in the hamlet's incidence of P. falciparum and P. vivax by 1 per 100 persons in a previous month resulted in 1.14 and 1.34 times increase in the risk of P. falciparum and P. vivax, respectively, among individuals in a particular hamlet. CONCLUSION: In a small area with low malaria transmission intensity, the variation in mosquito abundance is relatively similar across the residential areas; incidence of malaria between hamlets, which reflects the community level of human infectious reservoirs, is an important predictor for the malaria risk among individuals within these hamlets. Therefore, local malaria control strategies should focus on interventions that aim to reduce the gametocyte carriage in the population, such as early detection and treatment programmes and the use of ACT for P. falciparum.en
dc.format.extent1683883 bytesen
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.rightsMahidol Universityen
dc.subjectAntimalarialsen
dc.subjectMalariaen
dc.subjectMalaria, falciparumen
dc.subjectPlasmodium falciparumen
dc.subjectPopulation surveillanceen
dc.subjectRetrospective studiesen
dc.subjectOpen Access articleen
dc.titleThe impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar borderen
dc.typeArticleen
dc.rights.holderBioMed Central
dc.contributor.correspondenceSaranath Lawpoolsri
dc.date.accepted2010-05-26
dc.identifier.doi10.1186/1475-2875-9-143
dc.identifier.urlhttp://www.malariajournal.com/content/pdf/1475-2875-9-143.pdf
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