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Title: Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum
Authors: Chang Liu
Helen M. Ginn
Wanwisa Dejnirattisai
Piyada Supasa
Beibei Wang
Aekkachai Tuekprakhon
Rungtiwa Nutalai
Daming Zhou
Alexander J. Mentzer
Yuguang Zhao
Helen M.E. Duyvesteyn
César López-Camacho
Jose Slon-Campos
Thomas S. Walter
Donal Skelly
Sile Ann Johnson
Thomas G. Ritter
Chris Mason
Sue Ann Costa Clemens
Felipe Gomes Naveca
Valdinete Nascimento
Fernanda Nascimento
Cristiano Fernandes da Costa
Paola Cristina Resende
Alex Pauvolid-Correa
Marilda M. Siqueira
Christina Dold
Nigel Temperton
Tao Dong
Andrew J. Pollard
Julian C. Knight
Derrick Crook
Teresa Lambe
Elizabeth Clutterbuck
Sagida Bibi
Amy Flaxman
Mustapha Bittaye
Sandra Belij-Rammerstorfer
Sarah C. Gilbert
Tariq Malik
Miles W. Carroll
Paul Klenerman
Eleanor Barnes
Susanna J. Dunachie
Vicky Baillie
Natali Serafin
Zanele Ditse
Kelly Da Silva
Neil G. Paterson
Mark A. Williams
David R. Hall
Shabir Madhi
Marta C. Nunes
Philip Goulder
Elizabeth E. Fry
Juthathip Mongkolsapaya
Jingshan Ren
David I. Stuart
Gavin R. Screaton
Siriraj Hospital
Mahidol Oxford Tropical Medicine Research Unit
NIHR Oxford Biomedical Research Centre
Oxford University Hospitals NHS Foundation Trust
Texas A&M College of Veterinary Medicine & Biomedical Sciences
Public Health England
Diamond Light Source
University of the Witwatersrand Faculty of Health Sciences
University of Oxford
Fundacao Oswaldo Cruz
Fiocruz Amazônia
School of Pathology
University of Kent
Nuffield Department of Medicine
Università degli Studi di Siena
University of Oxford Medical Sciences Division
Oxford House
Fundação de Vigilância em Saúde do Amazonas
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 5-Aug-2021
Citation: Cell. Vol.184, No.16 (2021), 4220-4236.e13
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the United Kingdom. Here we study the ability of monoclonal antibodies and convalescent and vaccine sera to neutralize B.1.617.1 and B.1.617.2, complement this with structural analyses of Fab/receptor binding domain (RBD) complexes, and map the antigenic space of current variants. Neutralization of both viruses is reduced compared with ancestral Wuhan-related strains, but there is no evidence of widespread antibody escape as seen with B.1.351. However, B.1.351 and P.1 sera showed markedly more reduction in neutralization of B.1.617.2, suggesting that individuals infected previously by these variants may be more susceptible to reinfection by B.1.617.2. This observation provides important new insights for immunization policy with future variant vaccines in non-immune populations.
ISSN: 10974172
Appears in Collections:Scopus 2021

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