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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/792
Title: Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand.
Authors: Carrara, Verena I
Phyo, Aung P
Nwee, Paw
Soe, Ma
Htoo, Hsar
Jaruwan Arunkamomkiri
Pratap Singhasivanon
ประตาป สิงหศิวานนท์
Nosten, François
Mahidol University. Faculty of Tropical Medicine.
Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.
Nosten, François
Keywords: malaria;mefloquine-artesunate;north-western;Plasmodium falciparum;Thailand;uncomplicated;Open Access article
Issue Date: 6-Nov-2008
Citation: Carrara VI, Phyo AP, Nwee P, Soe M, Htoo H, Arunkamomkiri J. et al. Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand. Malar J. 2008 Nov 6;7:233.
Abstract: BACKGROUND: The use of artemisinin derivatives has increased exponentially with the deployment of artemisinin combination therapy (ACT) in all malarious areas. They are highly effective and are considered safe, but in animal studies artemisinin derivatives produce neurotoxicity targeting mainly the auditory and vestibular pathways. The debate remains as to whether artemisinin derivatives induce similar toxicity in humans. METHODS: This prospective study assessed the effects on auditory function of a standard 3-day oral dose of artesunate (4 mg/kg/day) combined with mefloquine (25 mg/kg) in patients with acute uncomplicated falciparum malaria treated at the Shoklo Malaria Research Unit, on the Thai-Burmese border. A complete auditory evaluation with tympanometry, audiometry and auditory brainstem responses (ABR) was performed before the first dose and seven days after initiation of the antimalarial treatment. RESULTS: Complete auditory tests at day 0 (D0) and day 7 (D7) were obtained for 93 patients. Hearing loss (threshold > 25 dB) on admission was common (57%) and associated with age only. No patient had a threshold change exceeding 10 dB between D0 and D7 at any tested frequency. No patient showed a shift in Wave III peak latency of more than 0.30 msec between baseline and D7. CONCLUSION: Neither audiometric or the ABR tests showed clinical evidence of auditory toxicity seven days after receiving oral artesunate and mefloquine.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/792
metadata.dc.identifier.url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590614/pdf/1475-2875-7-233.pdf
ISSN: 1475-2875 (electronic)
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