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Title: Women and other risk factors for chronic kidney disease of unknown etiology in Thailand: National Health Examination V Survey
Authors: Wichai Aekplakorn
Suwat Chariyalertsak
Pattapong Kessomboon
Sawitri Assanangkornchai
Surasak Taneepanichskul
Nareemarn Neelapaichit
Anchalee Chittamma
Chagriya Kitiyakara
Ramathibodi Hospital
Chulalongkorn University
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkia University
Chiang Mai University
Keywords: Multidisciplinary
Issue Date: 1-Dec-2021
Citation: Scientific Reports. Vol.11, No.1 (2021)
Abstract: There are limited data on chronic kidney disease of unknown etiology (CKDu) from Southeast Asia. Initially described in working age men, a common approach to detect CKDu that includes all adults has recently been proposed. We determined the prevalence, and risk factors for CKDu using data from a cross-sectional, nationally representative survey of the adult population of Thailand. We used a proxy for CKDu as age < 70 with impaired kidney function (eGFR < 60) in the absence of diabetes and hypertension (CKDu1) and heavy proteinuria (CKDu2). Prevalence estimates were probability-weighted for the Thai population. The associations between risk factors and CKDu or elderly subjects with eGFR < 60 without traditional causes were assessed by multivariable logistic regression. Of 17,329 subjects, the prevalence were: eGFR < 60, 5.3%; CKDu1 0.78%; CKDu2, 0.75%. CKDu differed by 4.3-folds between regions. Women, farmers/laborers, older age, gout, painkillers, rural area, and stones were independent risk factors for CKDu. Women, age, rural, gout, painkillers were significant risk factors for both CKDu and elderly subjects. These data collected using standardized methodology showed that the prevalence of CKDu in Thailand was low overall, although some regions had higher risk. Unlike other countries, Thai women had a two-fold higher risk of CKDu.
ISSN: 20452322
Appears in Collections:Scopus 2021

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