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Title: Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
Authors: Chaiwat Washirasaksiri
Weerachai Srivanichakorn
Ian F. Godsland
Chayanis Kositamongkol
Suwat Chariyalertsak
Pattapong Kessomboon
Sawitri Assanangkornchai
Surasak Taneepanichskul
Nareemarn Neelapaichit
Pochamana Phisalprapa
Desmond G. Johnston
Nick S. Oliver
Wichai Aekplakorn
Ramathibodi Hospital
Siriraj Hospital
Chulalongkorn University
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkia University
Imperial College Faculty of Medicine
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Chiang Mai University
Keywords: Multidisciplinary
Issue Date: 1-Dec-2021
Citation: Scientific Reports. Vol.11, No.1 (2021)
Abstract: Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a cross-sectional analysis from the National Health Examination Survey for Thailand (NHES-Thailand) and the Health Survey for England (HS-England) in adults aged 18–75 year. Glycaemia was assessed by FPG in Thailand and by HbA1c in the UK. In population- and gender-stratified analyses, the relationships between glycemia and lipids were explored. A total of 15,145 Thai and 3484 UK adults with blood measurement were included. The prevalences of prediabetes were: in NHES-Thailand, 16% (SE = 0.004), based on FPG (5.6 to < 7.0 mmol/L) and in HS-England, 19% (0.007) based on HbA1c (39 to < 48 mmol/mol). Increasingly abnormal glucose homeostasis was associated with increasing age, adiposity, SBP, proportion of antihypertensive and lipid-lowering agent use and with decreasing HDL-cholesterol. Independent of age, adiposity, smoking, alcohol, physical activity, and lipid and BP lowering drug use, increasing glycemia was associated with decreasing HDL-cholesterol specifically in women with prediabetes (NHES-Thailand, beta-coefficient − 0.07 (95% CI − 0.15, − 0.001) p = 0.04 and HS-England, − 0.03 (− 0.04, − 0.006) p = 0.01). In both populations, among those with prediabetes, increasing glycaemia is associated with an adverse, significant decline in HDL cholesterol, specifically in women. These adverse effects are apparent in widely-differing international populations.
ISSN: 20452322
Appears in Collections:Scopus 2021

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