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Title: Neutralizing dengue antibody in pregnant Thai women and cord blood.
Authors: Kriangsak Khamim
เกรียงศักดิ์ คำอิ่ม
Weerawan Hattasingh
วีรวรรณ หัตถสิงห์
Ananda Nisalak
Jaranit Kaewkungwal
จรณิต แก้วกังวาล
Fernandez, Stefan
Butsaya Thaisomboonsuk
บุษยา ไทยสมบูรณ์สุข
Krisana Pengsaa
กฤษณา เพ็งสา
Usa Thisyakorn
อุษา ทิสยากร
Mahidol University. Faculty of Tropical Medicine. Department of Tropical Pediatrics.
Mahidol University. Faculty of Tropical Medicine. Centre of Excellence for Biomedical & Public Health Informatics (BIOPHICS)
Mahidol University. Faculty of Tropical Medicine. Department of Tropical Hygiene.
Weerawan Hattasingh
Keywords: Antibody;Cord blood;Dengue;Neutralizing;Pregnant;Open Access article
Issue Date: 6-Feb-2015
Citation: Khamim K, Hattasingh W, Nisalak A, Kaewkungwal J, Fernandez S, Thaisomboonsuk B, et al. Neutralizing dengue antibody in pregnant Thai women and cord blood. PLoS Negl Trop Dis. 2015 Feb 6;9(2):e0003396.
Abstract: BACKGROUND: The WHO 'Global Strategy for Dengue Prevention and Control, 2012-2020' addresses the growing need for the treatment of dengue, and targets a 25% reduction in morbidity and 50% in mortality (using 2010 estimates as baseline). Achieving these goals requires future dengue prevention strategies that will employ both potential vaccines and sustainable vector-control measures. Maternally transferred dengue antibody is an important factor in determining the optimal age for dengue vaccination. OBJECTIVES: To estimate the seroprevalence of dengue antibodies among mothers living in an area of high endemicity--Ban Pong, Ratchaburi Province--and to assess maternal dengue antibodies transferred to cord blood. MATERIALS & METHODS: A cross-sectional study was conducted with 141 pregnant women who delivered at Ban Pong Hospital, Ratchaburi, Thailand. Maternal-cord paired sera were tested for dengue neutralizing (NT) antibody by PRNT50 assay. A ratio of ≥ 1:10 NT titer to dengue serotype was considered seropositive. RESULTS: Most mothers (137/141, 97.2%) had NT antibodies to at least one dengue serotype in their sera. At birth, the proportion of cord sera with NT antibodies to DEN-1, DEN-2, DEN-3, and DEN-4, were high and similar to the sera of their mothers, at 93.6%, 97.2%, 97.9%, and 92.2%, respectively. The dengue geometric mean titers (GMT) in cord blood were significantly higher than the maternal antibodies (p<0.001): highest in DEN-2, followed by DEN-3, and then DEN-1. The GMT of DEN-4 was the lowest among all four serotypes. CONCLUSIONS: Dengue infection is highly prevalent among pregnant women in this dengue-endemic area. Most of the cord blood had transferred dengue antibodies, which may have an impact on the disease burden in this population.
ISSN: 1935-2735 (electronic)
1935-2727 (printed)
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