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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/843
Title: Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
Authors: White, Nicholas J
Ashley, Elizabeth A
Recht, Judith
Delves, Michael J
Ruecker, Andrea
Smithuis, Frank M
Eziefula, Alice C
Bousema, Teun
Drakeley, Chris
Kesinee Chotivanich
เกศินี โชติวานิช
Mallika Imwong
มัลลิกา อิ่มวงศ์
Sasithon Pukrittayakamee
ศศิธร ผู้กฤตยาคามี
Jetsumon Prachumsri
เจตสุมน ประจำศรี
Chu, Cindy
Andolina, Chiara
Bancone, Germana
Hien, Tran T
Mayxay, Mayfong
Taylor, Walter RJ
Seidlein, Lorenz von
Price, Ric N
Barnes, Karen I
Djimdé, Abdoulaye
ter Kuile, Feiko
Gosling, Roly
Chen, Ingrid
Dhorda, Mehul J
Stepniewska, Kasia
Guérin, Philippe
Woodrow, Charles J
Dondorp, Arjen M
Day, Nicholas PJ
Nosten, Francois H
Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.
Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.
Mahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unit.
Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.
White, Nicholas J
Keywords: Drugs;Gametocytocidal;Malaria;Plasmodium falciparum;Therapeutic;Open Access article
Issue Date: 9-Dec-2014
Citation: White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, et al. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014 Dec 9;13:483.
Abstract: Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/843
metadata.dc.identifier.url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295364/pdf/12936_2014_Article_3664.pdf
ISSN: 1475-2875 (electronic)
Appears in Collections:TM-Article

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