Please use this identifier to cite or link to this item:
|Title:||Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.|
|Authors:||White, Nicholas J|
Ashley, Elizabeth A
Delves, Michael J
Smithuis, Frank M
Eziefula, Alice C
Hien, Tran T
Taylor, Walter RJ
Seidlein, Lorenz von
Price, Ric N
Barnes, Karen I
ter Kuile, Feiko
Dhorda, Mehul J
Woodrow, Charles J
Dondorp, Arjen M
Day, Nicholas PJ
Nosten, Francois H
Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.
Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.
Mahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unit.
Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.
White, Nicholas J
|Keywords:||Drugs;Gametocytocidal;Malaria;Plasmodium falciparum;Therapeutic;Open Access article|
|Citation:||White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, et al. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014 Dec 9;13:483.|
|Abstract:||Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.|
|Appears in Collections:||TM-Article|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.