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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/857
Title: Evaluation of a latex agglutination assay for the identification of Burkholderia pseudomallei and Burkholderia mallei.
Authors: Duval, Brea D.
Elrod, Mindy G.
Gee, Jay E.
Narisara Chantratita
นริศรา จันทราทิตย์
Sarunporn Tandhavanant
ศรัณย์พร ตันฑวนันท์
Direk Limmathurotsakul
ดิเรก ลิ้มมธุรสกุล
Hoffmaster, Alex R.
Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.
Mahidol University. Faculty of Tropical Medicine.Department of Tropical Hygiene.
Hoffmaster, Alex R.
Keywords: Burkholderia mallei;Burkholderia pseudomallei;Open Access article
Issue Date: 7-Apr-2014
Citation: Duval BD, Elrod MG, Gee JE, Chantratita N, Tandhavanant S, Limmathurotsakul D. et al. Evaluation of a latex agglutination assay for the identificationof Burkholderia pseudomallei and Burkholderia mallei. Am J Trop Med Hyg. 2014 Jun;90(6):1043-6.
Abstract: Cases of melioidosis and glanders are rare in the United States, but the etiologic agents of each disease (Burkholderia pseudomallei and Burkholderia mallei, respectively) are classified as Tier 1 select agents because of concerns about their potential use as bioterrorism agents. A rapid, highly sensitive, and portable assay for clinical laboratories and field use is required. Our laboratory has further evaluated a latex agglutination assay for its ability to identify B. pseudomallei and B. mallei isolates. This assay uses a monoclonal antibody that specifically recognizes the capsular polysaccharide produced by B. pseudomallei and B. mallei, but is absent in closely related Burkholderia species. A total of 110 B. pseudomallei and B. mallei were tested, and 36 closely related Burkholderia species. The latex agglutination assay was positive for 109 of 110 (99.1% sensitivity) B. pseudomallei and B. mallei isolates tested.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/857
metadata.dc.identifier.url: http://www.ajtmh.org/content/90/6/1043.full.pdf+html
ISSN: 0002-9637 (printed)
1476-1645 (electronic)
Appears in Collections:TM-Article

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