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dc.contributor.authorTakala-Harrisona, Shannonen_US
dc.contributor.authorClark, Taane G.en_US
dc.contributor.authorCummings, Michael P.en_US
dc.contributor.authorDondorp, Arjen M.en_US
dc.contributor.authorFukudaf, Mark M.en_US
dc.contributor.authorNosten, Francoisen_US
dc.contributor.authorNoedl, Haralden_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorมัลลิกา อิ่มวงศ์en_US
dc.contributor.authorBethell, Deliaen_US
dc.contributor.authorSe, Youryen_US
dc.contributor.authorLon, Chanthapen_US
dc.contributor.authorTyner, Stuart D.en_US
dc.contributor.authorSaunders, David L.en_US
dc.contributor.authorSocheat, Duongen_US
dc.contributor.authorAriey, Fredericen_US
dc.contributor.authorPhyo, Aung Pyaeen_US
dc.contributor.authorStarzengruber, Peteren_US
dc.contributor.authorFuehrer, Hans-Peteren_US
dc.contributor.authorSwoboda, Paulen_US
dc.contributor.authorStepniewska, Kasiaen_US
dc.contributor.authorFlegg, Jenniferen_US
dc.contributor.authorArze, Cesaren_US
dc.contributor.authorCerqueira, Gustavo C.en_US
dc.contributor.authorSilva, Joana C.en_US
dc.contributor.authorRicklefs, Stacy M.en_US
dc.contributor.authorPorcella, Stephen F.en_US
dc.contributor.authorStephens, Robert M.en_US
dc.contributor.authorAdams, Matthewen_US
dc.contributor.authorKenefic, Leo J.en_US
dc.contributor.authorCampino, Susanaen_US
dc.contributor.authorAuburn, Sarahen_US
dc.contributor.authorMacInnis, Bronwynen_US
dc.contributor.authorKwiatkowski, Dominic P.en_US
dc.contributor.authorSu, Xin-zhuanen_US
dc.contributor.authorWhite, Nicholas J.en_US
dc.contributor.authorRingwald, Pascalen_US
dc.contributor.authorPlowe, Christopher V.en_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Research Unit.en_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.en_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.-
dc.identifier.citationTakala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O, Dondorp AM. et al. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):240-5.en_US
dc.identifier.issn0027-8424 (printed)-
dc.identifier.issn1091-6490 (electronic)-
dc.description.abstractThe recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination. Identification of the genetic basis of resistance would provide tools for molecular surveillance, aiding efforts to contain resistance. Clinical trials of artesunate efficacy were conducted in Bangladesh, in northwestern Thailand near the Myanmar border, and at two sites in western Cambodia. Parasites collected from trial participants were genotyped at 8,079 single nucleotide polymorphisms (SNPs) using a P. falciparum-specific SNP array. Parasite genotypes were examined for signatures of recent positive selection and association with parasite clearance phenotypes to identify regions of the genome associated with artemisinin resistance. Four SNPs on chromosomes 10 (one), 13 (two), and 14 (one) were significantly associated with delayed parasite clearance. The two SNPs on chromosome 13 are in a region of the genome that appears to be under strong recent positive selection in Cambodia. The SNPs on chromosomes 10 and 13 lie in or near genes involved in postreplication repair, a DNA damage-tolerance pathway. Replication and validation studies are needed to refine the location of loci responsible for artemisinin resistance and to understand the mechanism behind it; however, two SNPs on chromosomes 10 and 13 may be useful markers of delayed parasite clearance in surveillance for artemisinin resistance in Southeast Asia.en_US
dc.rightsMahidol Universityen_US
dc.subjectDrug Resistanceen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectSelection, Geneticen_US
dc.subjectOpen Access articleen_US
dc.titleGenetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.en_US
dc.rights.holderPubMed Centralen_US
dc.contributor.correspondencePlowe, Christopher V.en_US
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