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Title: Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice.
Authors: Dutmanee Seriwatanachai
ดุษมณี เสรีวัฒนาชัย
Guo, Yuchen
Sun, Ningyuan
Duan, Xiaobo
Xu, Xin
Zheng, Liwei
Wang, Yongyue
Yuan, Quan
Mahidol University. Faculty of Dentistry. Department of Oral Biology
Keywords: Bone loss;CKD Mice;Estrogen;Open Access article
Issue Date: 17-Feb-2016
Citation: Guo Y, Sun N, Duan X, Xu X, Zheng L, Seriwatanachai D, Wang Y, Yuan Q.Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice. PLoS One. 2016 Feb 17;11(2):e0148804.
Abstract: BACKGROUND: Chronic kidney disease (CKD) has been regarded as a grave public health problem. Estrogen is a critical factor for both renal protection and bone remodeling. Our previous study demonstrated that CKD impairs the healing of titanium implants. The aim of this study was to investigate the effects of estrogen deficiency on the mandibular bone in CKD mice. METHODS: Forty eleven-week-old female C57BL mice were used in this study. Uremia and estrogen deficiency were induced by 5/6 nephrectomy and ovariectomy (OVX), respectively. After 8 weeks, the mice were sacrificed, and their mandibles were collected for micro-CT analysis and histological examination. RESULTS: All the mice survived the experimental period. Serum measurements confirmed a significant increase in BUN in the CKD group that was further increased by OVX. OVX led to significant decreases in both the BV/TV and cortical thickness of the mandibular bone in CKD mice. CONCLUSION: In summary, our findings indicate that estrogen deficiency leads to further mandibular bone loss in CKD mice.
ISSN: 1932-6203 (electronic)
Appears in Collections:DT-Article

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