Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/9509
Title: New lignans from anogeissus acuminata with HIV-1 reverse transcriptase inhibitory activity
Authors: Agnes M. Rimando
John M. Pezzuto
Norman R. Farnsworth
Thawatchai Santisuk
Vichai Reutrakul
Kazuko Kawanishi
University of Illinois at Chicago
Thailand Royal Forest Department
Mahidol University
Kobe Pharmaceutical University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-1994
Citation: Journal of Natural Products. Vol.57, No.7 (1994), 896-904
Abstract: Anolignan A [1] and anolignan B [3] are new dibenzylbutadiene lignans isolated from Anogeissus acuminata. Compounds 1 and 3 were identified as the active HIV-1 reverse transcriptase (RT) inhibitory constituents of this plant obtained by bioassay-guided fractionation. Compound 3, which was very weakly active when tested alone, showed high activity when combined with 1. The activity of 1 was likewise enhanced in the presence of 3. A concave isobole obtained from a plot of data derived from assays with 1 and 3 in combination indicated their synergistic effects. Another new lignan, anolignan C [5], and a known lignan, (—)- secoisolariciresinol [10] , were also isolated from this plant. Compounds 5 and 10 did not have activity against HIV -1 RT. Compounds 1,3 and 5 were either weakly cytotoxic or noncytotoxic when tested in various cancer cell lines. The structures of 1–5 and 10 were established by spectroscopic methods, especially by 1D and 2D nmr experiments. © 1994, American Chemical Society. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028103876&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/9509
ISSN: 15206025
01633864
Appears in Collections:Scopus 1991-2000

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.