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Title: | Plant Antitumor Agents. 31. The Calycopterones, a New Class of Biflavonoids with Novel Cytotoxicity in a Diverse Panel of Human Tumor Cell Lines |
Authors: | Monroe E. Wall Mansukh C. Wani Fekadu Fullas John B. Oswald Dan M. Brown Thawatchai Santisuk Vichai Reutrakul Andrew T. McPhail Norman R. Farnsworth John M. Pezzuto A. Douglas Kinghorn Jeffrey M. Besterman RTI International University of Illinois at Chicago The Forest Herbarium, Thailand Ministry of Natural Resources and Environment Mahidol University P.M. Gross Chemical Laboratory GlaxoSmithKline, USA Royal Forest Herbarium Duke University |
Keywords: | Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics |
Issue Date: | 1-May-1994 |
Citation: | Journal of Medicinal Chemistry. Vol.37, No.10 (1994), 1465-1470 |
Abstract: | Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4′,5-dihydroxy-3,3′,6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1–3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent. © 1994, American Chemical Society. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028318867&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/9513 |
ISSN: | 15204804 00222623 |
Appears in Collections: | Scopus 1991-2000 |
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