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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/9530
Title: Effects of compression force and type of fillers on release of diclofenac sodium from matrix tablets
Authors: Narong Sarisuta
Pilawan Mahahpunt
Mahidol University
Jawa Manufacturing Ltd.
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1994
Citation: Drug Development and Industrial Pharmacy. Vol.20, No.6 (1994), 1049-1061
Abstract: The influence of compression force and type of fillers on the release pattern of diclofenac sodium from wet-granulated tablet matrices containing Emcompress and lactose as fillers with Eudragit RSPM as a matrix additive was determined. The release pattern of diclofenac sodium from these matrices in USP phosphate buffer pH 7.2 at 37 ° C were found to be independent of compression forces whereas the ratios of insoluble (Emcompress) to soluble filler (lactose) appeared to greatly influence the drug release rate as evidenced in the increased release rate with decreasing Emcompress content. The kinetics of drug release was determined and found to precisely comform to the Higuchi's planar matrix model. A theoretical approach to predict the drug release rate from a designed system was presented and found to be satisfactorily predictive. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028210478&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/9530
ISSN: 03639045
Appears in Collections:Scopus 1991-2000

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