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|Title:||Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers|
K. N. Bangchang
I. W. Wainer
Hopital Pitie Salpetriere
Universite Paris-Sud XI
|Keywords:||Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||European Journal of Clinical Pharmacology. Vol.47, No.1 (1994), 85-87|
|Abstract:||We studied the pharmacokinetics of the enantiomers of mefloquine in whole blood in healthy Thai volunteers after administration of a single oral dose of 750 mg of the racemic mixture. Mefloquine pharmacokinetics were stereoselective. The peak concentrations and areas under the curve of the (-) enantiomer were significantly higher than those of its antipode (0.79 versus 0.46 μg · ml -1 and 402 versus 94 μg · h · ml -1 ). The half-lives of (-)MQ were significantly longer than those of (+)MQ (531 versus 206 h). No stereoselectivity was observed for t max values. © 1994 Springer-Verlag.|
|Appears in Collections:||Scopus 1991-2000|
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