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Title: Effects of Praziquantel on Human Intestinal Flukes (Fasciolopsis buski and Heterophyes Heterophyes)
Authors: H. Taraschewski
H. Mehlhorn
D. Bunnag
P. Andrews
H. Thomas
Ruhr-Universitat Bochum
Mahidol University
Bayer AG
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-1986
Citation: Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A. Vol.262, No.4 (1986), 542-550
Abstract: Human intestinal flukes (Fasciolopsis buski and Heterophyes heterophyes) were treated with praziquantel in vivo or in vitro and then studied by transmission (TEM) and scanning (SEM) electron microscopy. F. buski worms recovered from patients, which had been cured by oral treatment of 1 × 15, 1 × 25 or 1 × 40 mg praziquantel/kg body weight, showed typical contraction and alterations together with vacuolization and bleb formation of their tegument. H. heterophyes worms recovered from an experimentally infected dog were incubated in media containing 1 μg praziquantel/ml for 5–60 min. Their tegument showed lesions the extent and duration of which increased with exposure time, finally leading to death. The damage observed in vitro was very similar to that found in F. buski recovered from cured patients. The cure rate was very high when using 1 × 15 mg praziquantel/kg. © 1986, Gustav Fischer Verlag, Stuttgart · New York. All rights reserved.
ISSN: 01766724
Appears in Collections:Scopus 1969-1990

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