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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/9807
Title: NEW PURIFIED VERO-CELL VACCINE PREVENTS RABIES IN PATIENTS BITTEN BY RABID ANIMALS
Authors: Pravan Suntharasamai
D. A. Warrell
Sornchai Looareesuwan
M. J. Warrell
Chaisin Viravan
Wichai Supanaranond
Pornthep Chanthavanich
Achara Supapochana
Weera Tepsumethanon
X. Pouradier-Duteil
Mahidol University
Nuffield Department of Clinical Medicine
Thai Red Cross Agency
Institut Merieux
Keywords: Medicine
Issue Date: 19-Jul-1986
Citation: The Lancet. Vol.328, No.8499 (1986), 129-131
Abstract: The protective effect of a new, potentially economical tissue-culture rabies vaccine, purified vero-cell rabies vaccine (PVRV), was tested in 106 patients bitten by animals with proven rabies. 0·5 ml PVRV was given intramuscularly on days 0, 3, 7, 14, 28, and 91; 47 patients with severe exposure were also given 20 IU/kg human rabies immune globulin (HRIG). All patients are alive and well after 1 year. Side-effects of treatment were negligible. Rabies neutralising antibody (≥ 1·6 IU) was demonstrated on day 14 and persisted for 1 year in every case. There was no significant suppression of the antibody response by HRIG. If the untreated mortality is 15%, PVRV is 81% efficient in protecting patients against rabies encephalitis (95% confidence limit). PVRV is likely to replace human diploid-cell strain vaccine as the most widely used tissue-culture rabies vaccine. © 1986.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022655203&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/9807
ISSN: 01406736
Appears in Collections:Scopus 1969-1990

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