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Title: Retention of radioactive substances in the hypothalamus, anterior pituitary, and reproductive organs of male rats after 3H-melatonin administration
Authors: Boonsirm Withyachumnarnkul
Mookda Limpanawattanakul
Wantanee Trakulrungsi
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 12-May-1986
Citation: Life Sciences. Vol.38, No.19 (1986), 1757-1765
Abstract: Radioactive concentrations were determined in serum, lung, hypothalamus, anterior pituitary, testis, and accessory sex organs of adult male rats at 2, 20, 30 and 60 min after intravenous 3 H-melatonin administrations. The retention patterns of 3 H-melatonin and other radioactive substance ( 3 H-non-melatonin) in these tissues were compared. The anterior pituitary demonstrated best tissue retention with highest concentration of 3 H-melatonin. The testis and prostate gland accumulated 3 H-non-melatonin in an increasing manner from 2 to 60 min. The radioactive substances were also preferentially and progressively located in the nuclear fraction of the anterior pituitary, hypothalamus, testis, and prostate gland. This study leads to the following suggestions: (1) the anterior pituitary is another target organ of melatonin; (2) melatonin is converted into other active material which exerts its action in the testis and prostate gland; (3) melatonin and its active derivative exert their action through the nuclei of their respective cells. © 1986.
ISSN: 00243205
Appears in Collections:Scopus 1969-1990

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