Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/9869
Title: Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin B1 in rats
Authors: Chaivat Toskulkao
Thirayudh Glinsukon
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1986
Citation: Toxicology Letters. Vol.30, No.2 (1986), 151-157
Abstract: The binding of [ 3 H]aflatoxin B 1 (AFB 1 ) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of afb 1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB 1 metabolism by hepatic microsomes from ethanol-treated rats to aflatoxins m 1 (AFM 1 ) and Q 1 (AFQ 1 ) was increased when compared to those of control microsomes. These results suggest that an increase in AFB 1 binding to liver nucleic acids and AFB 1 metabolism after pretreatment of ethanol resulted from an increase in hepatic mixed-function oxidases and a possible decrease in hepatic glutathione (GSH) content which subsequently lead to an increase in hepatotoxicity of AFB 1 . © 1986.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022623439&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/9869
ISSN: 03784274
Appears in Collections:Scopus 1969-1990

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