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Title: Inhibitory effect of cytochalasins on the motility of rat epididymal spermatozoa in vitro
Authors: T. Glinsukon
S. Sinlapanapaporn
M. Chulasamaya
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1986
Citation: Research Communications in Chemical Pathology and Pharmacology. Vol.51, No.2 (1986), 265-268
Abstract: Cytochalasins, A, B, C, D and E at a concentration of 5.0 μg/ml significantly inhibited the motility of spermatozoa collected from the cauda epididymidis of rats when diluted in Hank's solution containing BSA by 21.6-38.1% within a few min incubation. The motility was significantly inhibited (approx. 16.7%) by Cyto. E at a concentration as low as 1.0 μg/ml within 30 min. This inhibitory effect of Cyto. E was a dose-dependent at the concentrations ranging from 1.0-20.0 μg/ml. These findings demonstrate that cytochalasins are powerful inhibitors on the motility of rat epididymal spermatozoa.
ISSN: 00345164
Appears in Collections:Scopus 1969-1990

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