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Title: The toxicity of betel nut extract determined by inhibition of microbial dehydrogenase activity
Authors: Sittichai Koontongkaew
Boonyanit Thaweboon
Rungsunn Tungtrongchitr
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1986
Citation: Toxicity Assessment. Vol.1, No.4 (1986), 419-429
Abstract: Dimethyl sulfoxide extracts of betel nut (100g/L) and betel leaf (100g/L), and methanol and water extracts of betel nut (100g/L) were found to inhibit dehydrogenase activity of Bacillus subtilis. In contrast betel nut (100g/L) extracted by petroleum ether showed no inhibitory effect. Thin layer chromatography, ultraviolet spectroscopy and total polyphenols estimation indicated that betel nut contained large amounts of polyphenols. On the basis of toxicity assessment, the results implied that betel nuts and betel leaves contained a hydrophilic element which was toxic to living cells. Copyright © 1986 Wiley Periodicals, Inc., A Wiley Company
ISSN: 10982256
Appears in Collections:Scopus 1969-1990

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