Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/9874
Title: Fengycin-A Novel Antifungal Lipopeptide Antibiotic Produced by Bacillus Subtilis F-29-3
Authors: Nongnuch Vanittanakom
Wolfgang Loeffler
Ulrike Koch
GüNther Jung
Mahidol University
Universitat Tubingen
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1986
Citation: Journal of Antibiotics. Vol.39, No.7 (1986), 888-901
Abstract: Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi but is ineffective against yeast and bacteria. The inhibition is antagonized by sterols, phospholipids and oleic acid, whereas two other unsaturated fatty acids increase the antifungal effect. Fengycin consists of two main components differing by one amino acid exchange. Fengycin A is composed of 1 D-Ala, 1 L-Ile, 1 L-Pro, 1 D-allo-Thr, 3 L-G1X, 1 D-Tyr, 1 L-Tyr, 1 D-Orn, whereas in fengycin B the D-Ala is replaced by D-Val. The lipid moiety of both analogs is more variable, as fatty acids have been identified as anteiso-pentadecanoic acid (ai-C 15 ), iso-hexadecanoic acid (i-C 16 ), n-hexadecanoic acid (n-C 16 ), and there is evidence for further saturated and unsaturated residues up to C 18 . © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022457256&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/9874
ISSN: 18811469
00218820
Appears in Collections:Scopus 1969-1990

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