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dc.contributor.authorSansanee C. Chaiyarojen_US
dc.contributor.authorRoss L. Coppelen_US
dc.contributor.authorSusanna Novakovicen_US
dc.contributor.authorGraham V. Brownen_US
dc.contributor.otherWalter Eliza Hall Inst. of Med. Res.en_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMonash Universityen_US
dc.date.accessioned2018-02-27T04:30:27Z-
dc.date.available2018-02-27T04:30:27Z-
dc.date.issued1994-11-08en_US
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. Vol.91, No.23 (1994), 10805-10808en_US
dc.identifier.issn00278424en_US
dc.identifier.other2-s2.0-0028116935en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028116935&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/9883-
dc.description.abstractA major virulence factor of Plasmodium falciparum is the adherence of parasitized erythrocytes to the wall of postcapillary venules via a specific interaction between parasite-derived erythrocyte surface ligands and receptors on endothelial cells. To study this phenomenon in vitro, we selected a parasite population that expressed at least two different ligands and demonstrated that parasitized cells may coexpress ligands with specificity for multiple receptors. This selected parasite line had several antigenic and cytoadherence characteristics that were different from those of the parent line. Single parasitized erythrocytes were able to adhere to three distinct receptors via at least two separate ligands; a trypsin-sensitive molecule mediated cytoadherence to CD36 and intercellular adhesion molecule I and a trypsin-insensitive molecule(s) was responsible for adherence to a third receptor on the surface of melanoma cells. We present evidence that this newly discovered receptor for cytoadherence is an N-linked glycosaminoglycan, as treatment of melanoma cells with endoglycosidase H abolished cytoadherence. These observations emphasize the adaptability of P. falciparum and the complexity of the cytoadherence phenomenon.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028116935&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleMultiple ligands for cytoadherence can be present simultaneously on the surface of Plasmodium falciparum-infected erythrocytesen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1073/pnas.91.23.10805en_US
Appears in Collections:Scopus 1991-2000

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