Browsing by Author "South China Normal University"
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Publication Metadata only Aerobic exercise induces tumor suppressor p16INK4a expression of endothelial progenitor cells in human skeletal muscle(2020-10-26) Jinfu Wu; I. Shiung Cheng; Suchada Saovieng; Wei Horng Jean; Chung Lan Kao; Yung Yang Liu; Chih Yang Huang; Tania Xu Yar Lee; John L. Ivy; Chia Hua Kuo; University of Taipei; National Taichung University of Education; National Yang-Ming University Taiwan; Far Eastern Memorial Hospital Taiwan; Tzu Chi University; The University of Texas at Austin; Mahidol University; South China Normal UniversityAerobic exercise induces oxidative stress and DNA damage, nevertheless, lowers cancer incidence. It remains unclear how genetic stability is maintained under this condition. Here, we examined the dynamic change of the tumor suppressor p16INK4a in cells of skeletal muscle among young men following 60-min of aerobic cycling at 70% maximal oxygen consumption (V̇O2max). Rg1 (5 mg, an immunostimulant ginsenoside) and placebo (PLA) were supplemented 1 h before exercise. Data from serial muscle biopsies shows unchanged p16INK4a+ cells after exercise followed by a considerable increase (+21-fold) in vastus lateralis muscle 3 h later. This increase was due to the accumulation of endothelial progenitor cells (p16INK4a+/CD34+) surrounding myofibers and other infiltrated nucleated cells (p16INK4a+/CD34-) in necrotic myofibers. During the Rg1 trial, acute increases of p16INK4a+ cells in the muscle occurred immediately after exercise (+3-fold) and reversed near baseline 3 h later. Rg1 also lowered IL-10 mRNA relative to PLA 3 h after exercise. Post-exercise increases in VEGF mRNA and CD163+ macrophages were similar for PLA and Rg1 trials. Conclusion: The marked increases in p16INK4a protein expression of endothelial progenitor cells in skeletal muscle implicates a protective mechanism for maintaining genetic stability against aerobic exercise. Rg1 accelerates resolution of the exercise-induced stress response.Publication Metadata only The associations between meeting 24-hour movement guidelines and adiposity in Asian Adolescents: The Asia-Fit Study(2020-01-01) Stanley Sai chuen Hui; Ru Zhang; Koya Suzuki; Hisashi Naito; Govindasamy Balasekaran; Jong Kook Song; Soo Yeon Park; Yiing Mei Liou; Dajiang Lu; Bee Koon Poh; Kallaya Kijboonchoo; Wiyada Thasanasuwan; Shanghai University of Sport; National Yang-Ming University Taiwan; Juntendo University; Yongin University; Mahidol University; South China Normal University; Nanyang Technological University; Chinese University of Hong Kong; Kyung Hee University; Universiti Kebangsaan Malaysia© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Less is known about how compliance with 24-hour movement guidelines for physical activity (PA), sedentary behavior, and sleep affects adiposity in young people. The purposes of this study were to compare compliance with 24-hour movement guidelines in Asian adolescents and to examine the associations between compliance with 24-hour movement guidelines and body fat percentage. A sample of 12 590 adolescents aged 13.63 (± 1.01) years from eight Asian metropolitan cities including Bangkok (Thailand), Hong Kong SAR, Kuala Lumpur (Malaysia), Seoul (South Korea), Shanghai (China), Singapore, Taipei (Taiwan), and Tokyo (Japan) completed interviewer-administered questionnaires to assess moderate-to-vigorous PA, recreational screen time, sleep duration, and covariates. Body fat percentage was measured using bioelectrical impedance analysis. We found that compliance with 24-hour movement guidelines differed in Asian adolescents across the eight cities. Adjusting for covariates, there was a negative association between number of the guidelines being met and body fat percentage in Asian adolescents. In addition, meeting only the sleep guideline and both the PA and sleep guidelines had negative associations with body fat percentage compared with no guidelines being met. Our findings improve the understanding about how compliance with 24-hour movement guidelines benefit a healthy body weight in adolescents, as well as contribute to development of evidence-based 24-hour movement guidelines for Asian young people. Future research is needed to gain better insights into the directionality of the associations between compliance with 24-hour movement guidelines and adiposity, as well as the mechanisms underlying the associations in Asian adolescents.Publication Metadata only A bibliometric study of the world's research activity in sustainable development and its sub-areas using scientific literature(2014-01-01) Saeed Ul Hassan; Peter Haddawy; Jia Zhu; COMSATS Institute of Information Technology Lahore; Mahidol University; South China Normal UniversityThis paper presents a bibliometric study of the world's research activity in Sustainable Development using scientific literature. The study was conducted using data from the Scopus database over the time period of 2000-2010. We investigated the research landscape in Sustainable Development at country level and at institute level. Sustainable Development and its sub-areas are defined by keywords vetted by the domain experts, allowing publications to be identified independent of the journals and conferences in which they are published. The results indicate that institutes strong in Sustainable Development overall may not be strong in all sub-areas and that institutes not strong in Sustainable Development overall may have significant niche strengths in a given sub-area. It is also noted that China appears strong in terms of publication output in Sustainable Development and its sub-areas but it does not appear strong in terms of citation counts. The information produced in this study can be useful for government research agencies in terms of understanding how to more effectively knit together the various niche strengths in the country; and for the institutes to find strategic partners that can coordinate in niche areas of Sustainable Development and complement their strengths. In order to conduct bibliometric analysis in an interdisciplinary research area, the keyword collection approach appears to be very useful. This approach is flexible and can be used to conduct such analysis for interdisciplinary research fields. © 2013 Akadémiai Kiadó, Budapest, Hungary.Publication Metadata only Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats(2019-11-01) Rungchai Chaunchaiyakul; Naruemon Leelayuwat; Jin Fu Wu; Chih Yang Huang; Chia Hua Kuo; University of Taipei; Faculty of Medicine, Khon Kaen University; Mahidol University; China Medical University Taichung; South China Normal University© 2019 Chinese Journal of Physiology | Published by Wolters Kluwer - Medknow. Ginsenoside profile of Panax ginseng is changing with season and cultivated soil. Yet, dose-response relationship of main ginsenosides on metabolic measures has not been documented in vivo. Here, we examined glucose and insulin responses after an oral glucose challenge (0.5 g/kg body weight) at various doses (0.01, 0.1, 1, and 10 mg/kg of body weight) under acute and chronic Rb1 and Rg1 supplemented conditions. The results show that Rb1 (0.01 and 0.1 mg/kg body weight) increased, whereas Rg1 (0.01 mg/kg body weight) decreased postprandial glucose levels compared with the Vehicle group (P < 0.05). This contrasting effect reduced as dose increased. Both Rb1 and Rg1 decreased the mitochondrial enzyme citrate synthase activity (P < 0.05) together with decreases in glycogen content in red gastrocnemius muscle and body temperature at low doses (P < 0.05), compared with the Vehicle group. These differences also diminished as dosage increases. For reliable ginseng research, dose standardization on Rg1 and Rb1 is essential based on their opposing action and peculiar dose-response relationship. Both major ginsenosides may influence dynamics of mitochondria turnover and alter muscle metabolism.Publication Metadata only Emerging contaminants in aquatic environments and coastal waters affected by urban wastewater discharge in Thailand: An ecological risk perspective(2020-11-01) Kanokthip Juksu; You Sheng Liu; Jian Liang Zhao; Li Yao; Charoon Sarin; Siranee Sreesai; Pantip Klomjek; Atsadang Traitangwong; Guang Guo Ying; Guangzhou Institute of Geochemistry Chinese Academy of Sciences; University of Chinese Academy of Sciences; Naresuan University; Mahidol University; South China Normal University; Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals© 2020 Elsevier Inc. Emerging contaminants such as synthetic musks and UV-filters as ingredients personal care products were widely used in human daily life in Thailand. The occurrence and fate of four synthetic musks and nine UV-filters were investigated in eight full-scale sewage treatment plants (STPs) and their receiving aquatic environments in Bangkok and Pattaya, Thailand. All target compounds were detected in every single sample from STPs and surface water with magnitude from ng/L to μg/L. HHCB-lactone and HMS were found as the predominant musk and UV filter in influent and effluent of STPs, respectively. HHCB-lactone was also found with the highest concentration up to 79501 ng/g (dw) in the sludge. Low removal efficiency range from −37% (HHCB-lactone) to 58% (AHTN) were found for four musks in the STPs. The total emission of Σ4musks and Σ9UV-filters were estimated to be up to 16.7 mg/person/day and 0.28 mg/person/day by the STPs. Three synthetic musks and seven UV-filters were detected in fish from the receiving river. Concentration and emission of musks and UV filters found in this study from Thailand were much higher than those reported in many other countries worldwide. The preliminary ecological risk assessment showed that Musk xylene, 4-MBC and OC may pose high risk to aquatic organisms in the riverine and estuarine environment in Thailand.Publication Metadata only Guidelines for the use and interpretation of assays for monitoring autophagy(2012-04-01) Daniel J. Klionsky; Fabio C. Abdalla; Hagai Abeliovich; Robert T. Abraham; Abraham Acevedo-Arozena; Khosrow Adeli; Lotta Agholme; Maria Agnello; Patrizia Agostinis; Julio A. Aguirre-Ghiso; Hyung Jun Ahn; Ouardia Ait-Mohamed; Slimane Ait-Si-Ali; Takahiko Akematsu; Shizuo Akira; Hesham M. Al-Younes; Munir A. Al-Zeer; Matthew L. Albert; Roger L. Albin; Javier Alegre-Abarrategui; Maria Francesca Aleo; Mehrdad Alirezaei; Alexandru Almasan; Maylin Almonte-Becerril; Atsuo Amano; Ravi Amaravadi; Shoba Amarnath; Amal O. Amer; Nathalie Andrieu-Abadie; Vellareddy Anantharam; David K. Ann; Shailendra Anoopkumar-Dukie; Hiroshi Aoki; Nadezda Apostolova; Giuseppe Arancia; John P. Aris; Katsuhiko Asanuma; Nana Y.O. Asare; Hisashi Ashida; Valerie Askanas; David S. Askew; Patrick Auberger; Misuzu Baba; Steven K. Backues; Eric H. Baehrecke; Ben A. Bahr; Xue Yuan Bai; Yannick Bailly; Robert Baiocchi; Giulia Baldini; Walter Balduini; Andrea Ballabio; Bruce A. Bamber; Edward T.W. Bampton; Gábor Bánhegyi; Clinton R. Bartholomew; Diane C. Bassham; Robert C. Bast; Henri Batoko; Boon Huat Bay; Isabelle Beau; Daniel M. Béchet; Thomas J. Begley; Christian Behl; Christian Behrends; Soumeya Bekri; Bryan Bellaire; Linda J. Bendall; Luca Benetti; Laura Berliocchi; Henri Bernardi; Francesca Bernassola; Sébastien Besteiro; Ingrid Bhatia-Kissova; Xiaoning Bi; Martine Biard-Piechaczyk; Janice S. Blum; Lawrence H. Boise; Paolo Bonaldo; David L. Boone; Beat C. Bornhauser; Karina R. Bortoluci; Ioannis Bossis; Frédéric Bost; Jean Pierre Bourquin; Patricia Boya; Michaël Boyer-Guittaut; Peter V. Bozhkov; Nathan R. Brady; Claudio Brancolini; Andreas Brech; Jay E. Brenman; University of Michigan, Ann Arbor; Universidade Federal de Sao Carlos; Hebrew University of Jerusalem; Pfizer Inc.; MRC Mammalian Genetics Unit; Hospital for Sick Children University of Toronto; Linkopings universitet; Universita degli Studi di Palermo; KU Leuven; New York University; Korea Institute of Science and Technology; Universite Paris 7- Denis Diderot; York University; Osaka University; The University of Jordan; Max Planck Institute for Infection Biology; Institut Pasteur, Paris; VAAAHS; University of Oxford; Universita degli Studi di Brescia, Facolta di Medicina e Chirurgia; Scripps Research Institute; Cleveland Clinic Foundation; Centro de Investigacion y de Estudios Avanzados; University of Pennsylvania; National Cancer Institute; Ohio State University; Universite Paul Sabatier Toulouse III; Iowa State University; City of Hope National Med Center; Griffith University; Niigata University; Universitat de Valencia, Facultad de Medicina y Odontologia; Istituto Superiore Di Sanita, Rome; University of Florida College of Medicine; Juntendo University; Norwegian Institute of Public Health; Kyoto University; Keck School of Medicine of USC; University of Cincinnati College of Medicine; Centre Mediterraneen de Medecine Moleculaire; Universite Nice Sophia Antipolis; Kogakuin University of Technology and Engineering; University of Massachusetts Medical School; University of North Carolina-Pembroke; General Hospital of People's Liberation Army; Universite de Strasbourg; University of Arkansas for Medical Sciences; Universita degli Studi di Urbino Carlo Bo; TIGEM Telethon Institute of Genetics and Medicine; Baylor College of Medicine; University of Toledo; University of Leicester; Semmelweis Egyetem; University of Texas MD Anderson Cancer Center; Universite Catholique de Louvain; Yong Loo Lin School of Medicine; Universite Paris-Sud XI; Universite d' Auvergne Clermont-FD 1; University at Albany State University of New York; Klinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizin; Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universitat Frankfurt am Main; CHU Hopitaux de Rouen; The University of Sydney; Merck & Co., Inc.; Universita degli studi Magna Graecia di Catanzaro; INRA Montpellier; Universita degli Studi di Roma Tor Vergata; CNRS Centre National de la Recherche Scientifique; Comenius University; Western University of Health Sciences; CNRS UM1; Indiana University School of Medicine Indianapolis; Emory University School of Medicine; Universita degli Studi di Padova; University of Chicago; Kinderspital Zurich; Universidade Federal de Sao Paulo; University of Maryland; CSIC - Centro de Investigaciones Biologicas (CIB); Universite de Franche-Comte; Sveriges lantbruksuniversitet; Universitat Heidelberg; Universita degli Studi di Udine; Universitetet i Oslo; University of North Carolina School of Medicine; de Duve Institute; University of Wisconsin School of Medicine and Public Health; Virginia Commonwealth University; University of Rochester Medical Center; Genentech Incorporated; Ottawa Hospital Research Institute; The University of North Carolina at Chapel Hill; Hertie-Institut fur klinische Hirnforschung; Medical University of Vienna Institute of Cancer Research; Universite de Geneve; Universidade de Sao Paulo - USP; NYU School of Medicine; Institutu Klinicke a Experimentalni Mediciny; Albert Einstein College of Medicine of Yeshiva University; Vanderbilt Eye Institute; Rutgers, The State University of New Jersey; Thomas Jefferson University; Universidad Autonoma de Madrid; Institut Biochimie et Genetique Cellulaires, Bordeaux; Royal Veterinary College University of London; Centro Europeo di Ricerca sul Cervello, Roma; CSIC - Instituto de Parasitologia y Biomedicina Lopez Neyra (IPBLN); Xiangya Hospital of Central-south University; University of Idaho; University of East Anglia; Universidade de Coimbra, Centro De Neurociencias e Biologia Celular; University of Texas Health Science Center at San Antonio; Case Western Reserve University; Lunds Universitet; Universidade Federal do Rio de Janeiro; Universita degli Studi di Modena e Reggio Emilia; University of Groningen, University Medical Center Groningen; Universita degli Studi di Messina; Universita Vita-Salute San Raffaele; Institut de Neurociencies, Universitat Autonoma de Barcelona; Universita degli Studi del Piemonte Orientale Amedeo Avogadro; University Medical Center Utrecht; Utrecht University; IRCCS Fondazione Santa Lucia; National Institutes of Health, Bethesda; Universitat Tubingen; Chonbuk National University; Kaohsiung Medical University Chung-Ho Memorial Hospital; California Institute of Technology; University of Strathclyde; The University of Hong Kong Li Ka Shing Faculty of Medicine; The University of Hong Kong; National Taiwan University College of Medicine; Academia Sinica Taiwan; Shanghai Jiao Tong University School of Medicine; Institute of Zoology Chinese Academy of Sciences; Nankai University; Institute of Biomedical Sciences Academia Sinica Taiwan; South China Normal University; Zhejiang University School of Medicine; Xijing Hospital; Tsinghua University; Peking University; University of Michigan Medical School; Mackay Memorial Hospital Taiwan; Purdue University; University of Louisville; Chinese University of Hong Kong; Penn State Hershey Cancer Institute; Memorial Sloan-Kettering Cancer Center; Yonsei University College of Medicine; Bond University; Physiopathologie du Cancer du Foie; Penn State College of Medicine; University of Tsukuba; National Yang-Ming University Taiwan; Kyung Hee University; Brigham and Women's Hospital; SungKyunKwan University, School of Medicine; Ajou University, School of Medicine; Institut de Cancerologie Gustave Roussy; University of Cincinnati; University of Tartu; University of Pittsburgh School of Medicine; National Health Research Institutes Taiwan; National Defense Medical Center Taiwan; Korea University; Universita degli Studi di Napoli Federico II; IRCCS San Raffaele Pisana; University of Liverpool; Safar Center for Resuscitation Research; Universitat Lausanne Schweiz; Lombardi Comprehensive Cancer Center; Inserm; Princeton University; Universidad Nacional de Cuyo; Universita degli Studi di Pavia; Johns Hopkins University; Pontificia Universidad Catolica de Chile; Universita degli Studi di Torino; David Geffen School of Medicine at UCLA; Universidad de Oviedo; Universidad de Valparaiso; University of Aberdeen; Keck Graduate Institute; CSIC-USE -Institute of Plant Biochemistry and Photosynthesis (IBVF); University of Johannesburg; University of Iowa; Universita Campus Bio-Medico di Roma; INRA Centre de Clermont-Ferrand-Theix; University of Cape Town; The Institute of Cancer Research, London; Karolinska University Hospital; Universita di Pisa; University of California, San Francisco; Tufts University School of Medicine; Institut des Maladies Neurodegeneratives; University of Melbourne; Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie; National University of Singapore; School of Life Sciences-LifeNet; Centre for Cancer Biology; University of Adelaide; University of New Mexico Health Sciences Center; LSU Health Sciences Center - New Orleans; Monash University; University of G. d'Annunzio Chieti and Pescara; Columbia University Medical Center; Consiglio Nazionale delle Ricerche; Universidad de Chile; Universidad de Alcala; Sanford Burnham Prebys Medical Discovery Institute; Frankfurt Institute for Molecular Life Sciences; University of California, Davis; University of Kansas Medical Center; University Hospitals Case Medical Center; Washington University School of Medicine in St. Louis; Validation et Identification de Nouvelles Cibles en Oncologie; Medical College of Georgia; Forschungszentrum Jülich (FZJ); Eli Lilly and Company; Bogomoletz Institute of Physiology; Ecole Normale Superieure de Lyon; Huazhong University of Science and Technology; Centre Hospitalier Universitaire Vaudois; Centre de Recherches BioMedicales des Cordeliers; Universite Pierre et Marie Curie; University of Colorado Health Sciences Center; University of California, Irvine; Universitat de Barcelona; University of Cologne; Milton S. Hershey Medical Center; Weizmann Institute of Science Israel; Universita degli Studi di Milano; Buck Institute for Age Research; Universiteit Stellenbosch; The Ruth and Bruce Rappaport Faculty of Medicine; Latvian Biomedical Research and Study Centre; Helsingin Yliopisto; George Mason University; Rutgers Robert Wood Johnson Medical School; Fudan University; UCSF Helen Diller Family Comprehensive Cancer Center; University of Maryland, Baltimore; Guangzhou University; King's College London; Kraeftens Bekaempelse; University of California, San Diego; Universite Claude Bernard Lyon 1; The University of Georgia; National Institute of Allergy and Infectious Diseases; University at Buffalo, State University of New York; Shanghai Jiao Tong University; Debreceni Egyetem Altalanos Orvostudomanyi Kar; San Diego State University; Hunter College; IRCCS Istituto Nazionale Malattie Infettive Lazzaro Spallanzani; National Heart, Lung, and Blood Institute; Rockefeller University; University of Colorado at Boulder; McGill University, Montreal Neurological Institute and Hospital; Universitatsklinikum Heidelberg; University of Nebraska Medical Center; University of Nebraska - Lincoln; Kobenhavns Universitet; Universidad de Extremadura; Kyushu University; Kagoshima University; Jichi Medical University; Tohoku University; Medizinische Hochschule Hannover (MHH); Szkola Glowna Gospodarstwa Wiejskiego; Indian Institute of Technology, Kanpur; University of Wisconsin Madison; University of Dundee; Institute of Microbiology Chinese Academy of Sciences; UT Southwestern Medical Center; Boston University; University of Illinois at Chicago; Centre dImmunologie de Marseille-Luminy; University of Kentucky; UCL Institute of Neurology; Harvard Medical School; University of Ottawa, Canada; University of Manitoba; University of California, San Diego, School of Medicine; Democritus University of Thrace; Manitoba Institute of Cell Biology; Lancaster University; Columbia University, College of Physicians and Surgeons; Medical University of Warsaw; New York Medical College; Ege Universitesi; Universidad de Buenos Aires; CSIC-CAR-UR - Instituto de Ciencias de la Vid y del Vino (ICVV); University of Nottingham; Uniformed Services University of the Health Sciences; British Columbia Cancer Agency; Sabanci Universitesi; Agricultural Institute of Slovenia; Children's Hospital of Iowa; Ludwig Boltzmann Institute; UCSD Medical Center, Moores Cancer Center; AstraZeneca; Montana State University - Bozeman; Osaka University Faculty of Medicine; Zhejiang University; Life Technologies; Virginia Commonwealth University Health System; University of Occupational and Environmental Health; John Radcliffe Hospital; Trinity College Dublin; Tokyo Metropolitan Institute of Medical Science; VA Medical Center; National Cerebral and Cardiovascular Center; Moffitt Cancer Center; UT Southwestern Medical School; Duke University School of Medicine; Centre Hospitalier de L'Universite de Montreal; University of Colorado School of Medicine; University of Glasgow; Facultad de Medicina de la Universidad de Chile; Riken; German Cancer Research Center; Universitat Bonn; Sun Yat-Sen University; Harvard University; LEO Pharma AS; University of Maryland School of Medicine; University of New Mexico School of Medicine; Providence Portland Medical Center; West China Hospital of Sichuan University; Mayo Clinic Cancer Center; National Taiwan University; Universitats Klinikum Freiburg und Medizinische Fakultat; Seoul National University; Chang Gung Memorial Hospital; University of Edinburgh; Chungnam National University; University of Washington, Seattle; McGill University; University of Durham; University of Ulsan, College of Medicine; Tokyo Women's Medical University; Asahi University; Universite de la Mediterranee Aix-Marseille II; Hong Kong University of Science and Technology; Nagoya University School of Medicine; Yale University School of Medicine; Keio University; Turku Centre for Biotechnology; UT Medical Branch at Galveston; Medical College of Wisconsin; Luxembourg Institute of Health; Seoul National University College of Medicine; Chungbuk National University; Harbin Medical University; Vanderbilt University Medical Center; Universidad de Salamanca; Korea Advanced Institute of Science & Technology; Universitetet i Tromso; University of Pittsburgh; University of Toronto; Universiteit van Pretoria; Eötvös Loránd University; Institut Universitaire de Pathologie, Lausanne; Korea Food Research Institute; Ita-Suomen yliopisto; National Institute of Neuroscience, Kodaira; National Institutes of Natural Sciences - National Institute for Basic Biology; Karolinska Institutet; Gifu University School of Medicine; National Cancer Centre, Singapore; University of Pittsburgh Cancer Institute; Kyushu University, Faculty of Medical Sciences; St. Jude Children Research Hospital; Tohoku University School of Medicine; Chang Gung University; University of Minnesota Cancer Center; Fraunhofer Institute for Cell Therapy and Immunology IZI; Wayne State University School of Medicine; Minufiya University; University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute (GBB); Hokkaido University; Gyeongsang National University (GSNU), College of Medicine; University of Minnesota Twin Cities; Daegu Gyeongbuk Institute of Science and Technology; Wonkwang University; Hallym University; University of Maryland, Baltimore County; Beatson Institute for Cancer Research; Rhode Island Hospital; Merck Serono, Darmstadt; Saint Boniface General Hospital Research Centre; University of Tokyo; Nagasaki University; Ludwig-Maximilians-Universitat Munchen; University of Arizona; Universitatsklinik Erlangen und Medizinische Fakultat; Centro de Investigacion Principe Felipe; Universitat Gottingen; Juntendo University School of Medicine; National Fisheries Research and Development Institute (NFRDI); Newcastle University, United Kingdom; Hiroshima University; Universitat Wien; Massachusetts General Hospital; Centre de Génétique et de Physiologie Moléculaire et Cellulaire; Universite Paris Descartes; The Babraham Institute; Cincinnati Children's Hospital Research Foundation; Institute of Biochemistry and Biophysics of the Polish Academy of Sciences; University of Louisville Health Sciences Center; The Commonwealth Medical College; UC Davis Comprehensive Cancer Center; Yonsei University; Rady Children's Hospital; Centre d'Infection et d'Immunite de Lille; Division of DermatologyLaval UniversityQuebec City; University of Bristol; Shanghai Institute for Biological Sciences Chinese Academy of Sciences; Cancer Research UK; Incheon National University; Samsung Medical Center, Sungkyunkwan University; The Catholic University of Korea; University of Florida; Institut de Recherche sur la Sante, l'Environnement et le Travail; University of Arkansas - Fayetteville; National Cheng Kung University; Fudan University Shanghai Medical College; Geisel School of Medicine at Dartmouth; Universidad de Santiago de Compostela; Medical University of South Carolina; Rush University Medical Center; Institut Jean-Pierre Bourgin; Third People's Hospital of Yongzhou; Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences Chinese Academy of Sciences; Hanshan Normal University; University of Texas Health Science Center at Houston; University of South Dakota, Sanford School of Medicine; Institute of Cellular and Organismic Biology, Academia Sinica; Medical University of Lodz; Konkuk University; College of Chemistry and Molecular Engineering, Peking University; National Institute of Child Health and Human Development; Duke University; Soochow University; Huazhong Normal University; Texas A and M Health Science Center; Stony Brook University; National Cancer Institute at Frederick; Shu-Te University; Queens College, City University of New York; Instituto Universitario de Oncologia del Principado de Asturias; Stanford University School of Medicine; Van Andel Research Institute; Karl-Franzens-Universitat Graz; IRCCS San Raffaele Scientific Institute; National Human Genome Research Institute; San Raffaele Institute Sulmona; Hefei National Laboratory for Physical Sciences at Microscale; Research Center Caesar; Nanjing Agricultural University; Feinstein Institute for Medical Research; University of Ottawa Heart Institute; Cambridge Institute for Medical Research; Agricultural Biotechnology Research Institute of Iran; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas; Universite de Montpellier; Universiteit Antwerpen; Vall d'Hebron Institut de Recerca; Osaka Prefecture University; Malaghan Institute of Medical Research; Cork Cancer Research Centre; Vanderbilt University; Dalhousie University; Academic Medical Centre, University of Amsterdam; Yale University; Hospital Ramon y Cajal; Institute Catala Oncologia; Fundacao Oswaldo Cruz; Bernhard Nocht Institut fur Tropenmedizin Hamburg; Second Military Medical University; Shandong University; University of Namur; Max Delbruck Center for Molecular Medicine; Universita degli Studi di Siena; Tokyo Medical University; Tokyo Medical and Dental University; FONDATION ARC POUR LA RECHERCHE SUR LE CANCER; Hospital Universitari Vall d'Hebron; International University of Health and Welfare; University of Iowa Healthcare; Plymouth Marine Laboratory; Universidad de Costa Rica; Saitama University; Imperial College London; Wellcome Trust Centre for Molecular Parasitology; Georgetown University Medical Center; IRCCS Saverio de Bellis; University Hospital Zurich Institute of Experimental Immunology; Novartis Institutes for BioMedical Research, Inc.; The Wistar Institute; Universita degli Studi di Roma La Sapienza; Tokai University School of Medicine; Kyoto Sangyo University; Tokyo Institute of Technology; University of South Florida, Tampa; National Institute of Neurological Disorders and Stroke; Radboud University Nijmegen Medical Centre; New York Blood Center; Southern Illinois University School of Medicine; University of Split; National Institute of Infectious Diseases; Riken Brain Science Institute; Institute of Medical Science The University of Tokyo; Jikei University School of Medicine; Ecole Polytechnique Federale de Lausanne; Sanford-Burnham Medical Research Institute at Lake Nona; University of Hawaii at Manoa; University of Athens; Yonsei University Wonju Campus; University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh; Universita della Calabria; University of Texas at San Antonio; Duke-NUS Graduate Medical School Singapore; ETH Zurich; VU University Medical Center; Retrovirus endogenes et elements retroides des eucaryotes superieurs; Tel Aviv University; Jules Stein Eye Institute; Northwestern University Feinberg School of Medicine; Institut Claudius Regaud; Dynamique Des Microtubules En Physiopathologie; Consejo Superior de Investigaciones Científicas; IRO-Institute for Research in Ophthalmology; University of Florida College of Dentistry; Columbia University in the City of New York; Cornell University; Institute of Basic Medical Sciences Chinese Academy of Medical Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; The University of British Columbia; Goethe-Universitat Frankfurt am Main; The Medical Research Council Laboratory of Molecular Biology; Food and Drug Administration; EMD Serono Research Institute; University of South Carolina School of Medicine; University of Waterloo; Wayne State University; University of Wyoming College of Health Sciences; Universidade Federal de Minas Gerais; Cincinnati Children's Hospital Medical Center; Centre Hospitalier Universitaire de Nice, Hopital l'Archet; University of South Carolina; University of Silesia in Katowice; Maastricht University; Taussig Cancer Center; Universitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat; Ben-Gurion University of the Negev; Charles University; Massachusetts Institute of Technology; Whitehead Institute for Biomedical Research; University of Medicine and Dentistry of New Jersey; Meikai University; UCL Cancer Institute; CSIC-JA-UPO - Centro Andaluz de Biología del Desarrollo (CABD); Centro Regional de Investigaciones Biomedicas, Universidad de Castilla-La Mancha; Dulbecco Telethon Institute; Venetian Institute of Molecular Medicine; Stanford University; Jawaharlal Nehru University; Vilniaus universitetas; Gunma University; UniversitatsSpital Zurich; University of Wyoming; Universitatsklinikum Ulm; Friedrich-Alexander-Universität Erlangen-Nürnberg; Universitat fur Bodenkultur Wien; Vanderbilt University School of Medicine; Rikshospitalet-Radiumhospitalet HF; Durham VA Medical Center; INRA Bordeaux-Aquitaine; Drexel University College of Medicine; Korea Basic Science Institute; University of Alabama at Birmingham; Jefferson Medical College; Hebrew University-Hadassah Medical School; Howard Hughes Medical Institute; University of Southern California, School of Pharmacy; NARO Institute of Floricultural Science; National Chung Hsing University; Taipei Medical University; McGill University, Rosalind and Morris Goodman Cancer Research Centre; Institute of Cell Biology National Academy of Sciences of Ukraine; Royal North Shore Hospital; Weatherall Institute of Molecular Medicine; Nuffield Department of Clinical Medicine; Universitat Bern; Consorzio Mario Negri Sud; The Johns Hopkins School of Medicine; Hong Kong Polytechnic University; University of Chemistry and Technology, Prague; Lomonosov Moscow State University; Mahidol University; Centro Nacional de Investigaciones Oncologicas; Hebei Medical University; Charité – Universitätsmedizin Berlin; Mayo Clinic in Jacksonville, Florida; Indian Institute of Science Education and Research Thiruvananthapuram; Academy of Athens; UCL; SAIC-Frederick; Instituto Nacional de Cancer; Heinrich Heine Universitat; CASE School of Medicine; Wuhan University; University of the Ryukyus; University of York; University of Texas Medical School at Houston; Yokohama City University School of Medicine; University of Exeter; Chinese Academy of Sciences; Institute of Genetics and Developmental Biology Chinese Academy of Sciences; University of Birmingham; Universita degli Studi dell'Insubria; Okayama University Medical School; University of Cambridge; University of Manchester; University of Southern California; University of Belgrade; UniversitatsSpital Bern; University of Pittsburgh Medical Center; Jozef Stefan Institute; Francis Marion University; OHSU School of Medicine; IRCCS Casa Sollievo della Sofferenza; Vrije Universiteit Brussel; Universiteit Gent; KU Leuven– University Hospital Leuven; Hospital Clinic Barcelona; Universidad Complutense de Madrid; Universitat Autònoma de Barcelona; Komarov Botanical Institute, Russian Academy of Sciences; Cardiff University; Texas A and M Institute for Biosciences and Technology; North Shore University Hospital; National Tsing Hua University; Chinese Academy of Medical Sciences; Changzheng Hospital; Nijmegen Centre for Molecular Life Sciences - NCMLS; University of Utah, School of Medicine; House Research Institute; University of Science and Technology of China; University of Sheffield; University Health Network University of Toronto; Fujian University of Traditional Chinese Medicine; Xi'an Jiaotong University; University of Southampton; Wuhan Institute of Virology Chinese Academy of Sciences; University of Oklahoma Health Sciences Center; Henan University of Technology; University of Kansas Lawrence; Mayo Clinic; Nagahama Institute of Bio-Science and Technology; National Research Institute of Fisheries Science, FRA; Okinawa Institute of Science and Technology Graduate University; OIST Graduate University; Vanderbilt Ingram Cancer Center; Weis Center for Research; University of Shizuoka; INRA Centre de Recherche de Versailles-Grignon; Chosun University; Icahn School of Medicine at Mount Sinai; Keio University School of Medicine; Toronto General Research Institute University of Toronto; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; University of Virginia; National Institute of Biological Sciences, Beijing; Leiden University Medical Center - LUMC; University of Newcastle Faculty of Medicine and Health Sciences; Peking University Health Science Center; University of California, Berkeley; Goteborgs Universitet; Max Planck Institut fur Psychiatrie; Centre Hospitalier Universitaire de Nice; Istituto Neurologico Mediterraneo Neuromed, Pozzilli; The Cancer Institute of New Jersey; Universite de Lyon; Panepistimio Kritis; Santo Tomas University; Johannes Gutenberg Universitat Mainz; University of RzeszowIn 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field. © 2012 Landes Bioscience.Publication Metadata only Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1(2021-01-01) Chao Chieh Hsieh; Chiung Yun Chang; Tania Xu Yar Lee; Jinfu Wu; Suchada Saovieng; Yu Wen Hsieh; Maijian Zhu; Chih Yang Huang; Chia Hua Kuo; Tzu Chi University of Science and Technology; University of Taipei; Asia University; China Medical University Hospital; Buddhist Tzu-Chi General Hospital Taiwan; Mahidol University; China Medical University; South China Normal UniversityBackground: Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. Purpose: To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1. Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results: No significant differences in longevity (control: 706 days; Rg1: 651 days, p = 0.77) and tumor incidence (control: 19%; Rg1: 12%, p = 0.24) were observed between the two groups. Movement distance in the control group declined significantly by ∼60% at 21 months of age, together with decreased TNF-α (p = 0.01) and increased IL-10 (p = 0.02). However, the movement distance in the Rg1 group was maintained ∼50% above the control groups (p = 0.01) at 21 months of age with greater magnitudes of TNF-α decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period. Conclusion: The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.Publication Metadata only Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals(2020-01-01) Suchada Saovieng; Jinfu Wu; Wei Horng Jean; Chih Yang Huang; Matthew F. Higgins; Ahmad Alkhatib; Mallikarjuna Korivi; Chiao Nan Chen; Chia Hua Kuo; Tzu Chi University of Science and Technology; University of Taipei; National Yang-Ming University Taiwan; Far Eastern Memorial Hospital Taiwan; China Medical University Hospital Taichung; Teesside University; Buddhist Tzu-Chi General Hospital Taiwan; Tzu Chi University; University of Derby; Mahidol University; China Medical University Taichung; South China Normal University; Zhejiang Normal University© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague Dawley rats, randomized into four groups: Control (C), DOM (D), Fructose (F), and Fructose + DOM (FD). Fructose drink contained 11% fructose. Tumor incidence (necropsy at death) in the D group was ~40% lower than that in the C group (P <.05), together with lower body mass gain and greater locomotive activity during their initial 18 months (P <.05) but not during later life. X-ray image analysis on abnormal solid tissue among survivors at 18 and 24 months of age confirms a similar trend, exhibiting ~50% and ~65% lower tumor incidence than the C and F groups, respectively. Reduced-to-oxidized glutathione ratio (GSH/GSSG) declined with age for the first three quarters of life on all groups (P <.05), followed by a resurgence during end-life among survivors at 24 months. This resurgence is markedly associated with lower tumor expansion but unrelated with DOM supplementation. Our results demonstrate valuable application of minerals and trace elements from deep oceans, as a vastly available natural source, on tumor suppression during normal aging.Publication Metadata only Occurrence, fate and risk assessment of biocides in wastewater treatment plants and aquatic environments in Thailand(2019-11-10) Kanokthip Juksu; Jian Liang Zhao; You Sheng Liu; Li Yao; Charoon Sarin; Siranee Sreesai; Pantip Klomjek; Yu Xia Jiang; Guang Guo Ying; Guangzhou Institute of Geochemistry Chinese Academy of Sciences; University of Chinese Academy of Sciences; Naresuan University; Mahidol University; South China Normal University© 2019 Elsevier B.V. This study investigated the occurrence and fate of 19 biocides in 8 wastewater treatment plants and receiving aquatic environments (both freshwater and estuarine systems) in Thailand. The predominant compound in wastewater and surface water was methylparaben with the maximum concentration of 15.2 μg/L detected in the receiving river, while in sludge and sediment was triclocarban with the maximum concentration of 8.47 μg/g in sludge. Triclosan was the main contaminants in the fish samples with the maximum concentration of 1.20 μg/g. Similar results of biocides were found in the estuarine system in Pattaya city, with the maximum concentration of 185 ng/L in sea water for methylparaben, and 242 ng/g in estuarine sediment for triclocarban. The aqueous removal rates for the biocides ranged from 15% to 95% in average. The back estimated-usage and total estimated emission of Ʃ19 biocides in Thailand was 279 and 202 tons/year, respectively. Preliminary ecological risk assessment showed that clotrimazole and triclosan could pose high risks to aquatic organisms in the receiving aquatic environments.Publication Metadata only Parasites and asthma(2017-09-01) Lin Wuhao; Chen Ran; He Xujin; Wu Zhongdao; Paron Dekumyoy; Lv Zhiyue; Sun Yat-Sen University, Zhongshan School of Medicine; Sun Yat-Sen University; South China Normal University; Provincial Engineering Technology Research Center for Biological Vector Control; Mahidol University© 2017, Springer-Verlag GmbH Germany. Nowadays, many studies have found low morbidity of asthma in epidemic areas of parasitic diseases, as shown by the hygiene hypothesis. It is obvious that some parasite infections can prevent asthma and studies have been carried out to clarify the mechanism of the preventive effect and search for the future asthmatic therapies. Previous findings have indicated that this mechanism may be related to the immune response switching from Th1 to Th2 and important cells induced by parasites, including the regulatory T cells, regulatory B cells, dendrite cells, and alternatively activated macrophages. Cytokine IL-10 also plays a nonredundant role in protection against allergic airway inflammation in asthma. This review focuses on the relationship between parasites and asthma, and the potential protection mechanism involved.