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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

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2022-02-03
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10974172
00928674
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10.1016/j.cell.2021.12.046
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2-s2.0-85123365266
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item.page.oaire.edition
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Mahidol University
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Cell. Vol.185, No.3 (2022), 467-484.e15
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Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiří Zahradník, Piyada Supasa, Chang Liu, Helen M.E. Duyvesteyn, Helen M. Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite, Suman Khan, Ori Avinoam, Mohammad Bahar, Donal Skelly, Sandra Adele, Sile Ann Johnson, Ali Amini, Thomas G. Ritter, Chris Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nicola Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K. Aley, Merryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Vicky Baillie, Natali Serafin, Gaurav Kwatra, Kelly Da Silva, Shabir A. Madhi, Marta C. Nunes, Tariq Malik, Peter J.M. Openshaw, J. Kenneth Baillie, Malcolm G. Semple, Alain R. Townsend, Kuan Ying A. Huang, Tiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Bede Constantinides, Hermione Webster, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Christopher Conlon, Alexandra S. Deeks, John Frater, Lisa Frending, Siobhan Gardiner, Anni Jämsén, Katie Jeffery, Tom Malone, Eloise Phillips, Lucy Rothwell, Lizzie Stafford, J. Kenneth Baillie, Peter JM Openshaw, Gail Carson, Beatrice Alex, Petros Andrikopoulos, Benjamin Bach, Wendy S. Barclay, Debby Bogaert, Meera Chand, Kanta Chechi, Graham S. Cooke, Ana da Silva Filipe, Thushan de Silva, Annemarie B. Docherty, Gonçalo dos Santos Correia, Marc Emmanuel Dumas, Jake Dunning, Tom Fletcher, Christoper A. Green, William Greenhalf, Julian L. Griffin, Rishi K. Gupta, Ewen M. Harrison, Julian A. Hiscox, Antonia Ying Wai Ho, Peter W. Horby, Samreen Ijaz (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/73427.
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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Alternative Title(s)
Author(s)
Wanwisa Dejnirattisai
 Jiandong Huo
 Daming Zhou
 Jiří Zahradník
 Piyada Supasa
 Chang Liu
 Helen M.E. Duyvesteyn
 Helen M. Ginn
 Alexander J. Mentzer
 Aekkachai Tuekprakhon
 Rungtiwa Nutalai
 Beibei Wang
 Aiste Dijokaite
 Suman Khan
 Ori Avinoam
 Mohammad Bahar
 Donal Skelly
 Sandra Adele
 Sile Ann Johnson
 Ali Amini
 Thomas G. Ritter
 Chris Mason
 Christina Dold
 Daniel Pan
 Sara Assadi
 Adam Bellass
 Nicola Omo-Dare
 David Koeckerling
 Amy Flaxman
 Daniel Jenkin
 Parvinder K. Aley
 Merryn Voysey
 Sue Ann Costa Clemens
 Felipe Gomes Naveca
 Valdinete Nascimento
 Fernanda Nascimento
 Cristiano Fernandes da Costa
 Paola Cristina Resende
 Alex Pauvolid-Correa
 Marilda M. Siqueira
 Vicky Baillie
 Natali Serafin
 Gaurav Kwatra
 Kelly Da Silva
 Shabir A. Madhi
 Marta C. Nunes
 Tariq Malik
 Peter J.M. Openshaw
 J. Kenneth Baillie
 Malcolm G. Semple
 Alain R. Townsend
 Kuan Ying A. Huang
 Tiong Kit Tan
 Miles W. Carroll
 Paul Klenerman
 Eleanor Barnes
 Susanna J. Dunachie
 Bede Constantinides
 Hermione Webster
 Derrick Crook
 Andrew J. Pollard
 Teresa Lambe
 Christopher Conlon
 Alexandra S. Deeks
 John Frater
 Lisa Frending
 Siobhan Gardiner
 Anni Jämsén
 Katie Jeffery
 Tom Malone
 Eloise Phillips
 Lucy Rothwell
 Lizzie Stafford
 J. Kenneth Baillie
 Peter JM Openshaw
 Gail Carson
 Beatrice Alex
 Petros Andrikopoulos
 Benjamin Bach
 Wendy S. Barclay
 Debby Bogaert
 Meera Chand
 Kanta Chechi
 Graham S. Cooke
 Ana da Silva Filipe
 Thushan de Silva
 Annemarie B. Docherty
 Gonçalo dos Santos Correia
 Marc Emmanuel Dumas
 Jake Dunning
 Tom Fletcher
 Christoper A. Green
 William Greenhalf
 Julian L. Griffin
 Rishi K. Gupta
 Ewen M. Harrison
 Julian A. Hiscox
 Antonia Ying Wai Ho
 Peter W. Horby
 Samreen Ijaz
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Mahidol Oxford Tropical Medicine Research Unit
 NIHR Oxford Biomedical Research Centre
 Oxford University Hospitals NHS Foundation Trust
 Texas A&M College of Veterinary Medicine & Biomedical Sciences
 Public Health England
 Diamond Light Source
 University of the Witwatersrand Faculty of Health Sciences
 Chang Gung University College of Medicine
 University of Leicester
 University Hospitals of Leicester NHS Trust
 University of Oxford
 University of Edinburgh, Roslin Institute
 Fundacao Oswaldo Cruz
 University of Liverpool
 Fiocruz Amazônia
 Weizmann Institute of Science Israel
 School of Pathology
 National Heart and Lung Institute
 Nuffield Department of Medicine
 Università degli Studi di Siena
 University of Oxford Medical Sciences Division
 Fundação de Vigilância em Saúde do Amazonas
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Abstract
On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.
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Biochemistry, Genetics and Molecular Biology
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https://repository.li.mahidol.ac.th/handle/123456789/73427
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Scopus 2022