Anti-carcinoembryonic antigen conjugated resveratrol/sunitinib-loaded polymeric nanoparticles for therapeutic enhancement in colorectal cancer
4
Issued Date
2026-10-01
Resource Type
ISSN
01418130
eISSN
18790003
Scopus ID
2-s2.0-105045454334
Pubmed ID
42448198
Journal Title
International Journal of Biological Macromolecules
Volume
377
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Biological Macromolecules Vol.377 (2026)
Suggested Citation
Nonsuwan P., Insawang K., Niwetbowornchai N., Taya S., Srisawat C., Dana P., Saengkrit N., Nguyen T., Punnakitikashem P. Anti-carcinoembryonic antigen conjugated resveratrol/sunitinib-loaded polymeric nanoparticles for therapeutic enhancement in colorectal cancer. International Journal of Biological Macromolecules Vol.377 (2026). doi:10.1016/j.ijbiomac.2026.153540 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/118234
Title
Anti-carcinoembryonic antigen conjugated resveratrol/sunitinib-loaded polymeric nanoparticles for therapeutic enhancement in colorectal cancer
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Corresponding Author(s)
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Abstract
Colorectal cancer treatment remains limited by poor tumor selectivity, systemic toxicity, and insufficient delivery of combination therapies to three-dimensional tumor-like structures. This study investigates the development and application of anti-carcinoembryonic antigen (anti-CEA) conjugated polymeric nanoparticles co-loaded with sunitinib (SUN) and resveratrol (RSV) for the treatment of colorectal cancer. The nanoparticles, formulated using poly(lactic-co-glycolic acid) (PLGA), exhibited favorable physicochemical properties, including a particle size of 207.6 ± 19.0 nm and a negative surface charge of −24.8 ± 0.7 mV. The nanoparticles exhibited controlled and sustained drug release, enabling the prolonged therapeutic efficacy of SUN and RSV. Functionalization with anti-CEA antibodies enabled selective targeting of colorectal cancer cells, as demonstrated by enhanced internalization in HCT-116 cells with high CEA expression. Consistent with this targeting effect, the anti-CEA-conjugated nanoparticles achieved a 29% relative reduction in cell viability against HCT-116 cells compared to non-targeted counterparts in two-dimensional cultures. Furthermore, the SUN and RSV combination exhibited potent synergistic effects across three-dimensional spheroid models. The anti-CEA functionalized system proved more effective, reducing spheroid volume and cell viability by 10% and 14%, respectively, compared to the non-targeted nanoparticles. These findings highlight the potential of CEA-targeted polymeric nanoparticles for co-delivery of synergistic anticancer agents, offering a promising strategy for colorectal cancer therapy.