Challenges to Accessing Newer Antibiotics for Multidrug-resistant Bacterial Infections in Asia: A Literature Review of Multi-Stakeholder Perspectives
7
Issued Date
2026-05-15
Resource Type
ISSN
10584838
eISSN
15376591
Scopus ID
2-s2.0-105040842827
Pubmed ID
42227054
Journal Title
Clinical Infectious Diseases
Volume
82
Start Page
S154
End Page
S161
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Infectious Diseases Vol.82 (2026) , S154-S161
Suggested Citation
Aligui A.F., Hor S.W., Blanco-Arévalo A., Gupta A., Saravanan R., Leong J., Olney J., Shou Y., Chee J.Y., Yap R., Singh S.R., Mo Y. Challenges to Accessing Newer Antibiotics for Multidrug-resistant Bacterial Infections in Asia: A Literature Review of Multi-Stakeholder Perspectives. Clinical Infectious Diseases Vol.82 (2026) , S154-S161. S161. doi:10.1093/cid/ciag024 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/117245
Title
Challenges to Accessing Newer Antibiotics for Multidrug-resistant Bacterial Infections in Asia: A Literature Review of Multi-Stakeholder Perspectives
Author's Affiliation
National University of Singapore
NUS Yong Loo Lin School of Medicine
Nuffield Department of Medicine
The University of Sydney School of Medicine
Duke-NUS Medical School
Hospital Universitari de Bellvitge
School of Medicine and Psychology
Mahidol Oxford Tropical Medicine Research Unit
Clinton Health Access Initiative, Inc.
The Medical City
NUS Yong Loo Lin School of Medicine
Nuffield Department of Medicine
The University of Sydney School of Medicine
Duke-NUS Medical School
Hospital Universitari de Bellvitge
School of Medicine and Psychology
Mahidol Oxford Tropical Medicine Research Unit
Clinton Health Access Initiative, Inc.
The Medical City
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Asia faces significant barriers to accessing newer antibiotics despite a high burden of antimicrobial resistance. Methods: We conducted a literature review to identify key gaps and challenges in access to newer antibiotics in Asian countries. Peer-reviewed and gray literature from January 2010 to October 2024 were searched for articles discussing access to Food and Drug Administration (FDA)-approved antibiotics post-2010 with an Asian perspective. A total of 134 articles were reviewed. Results: Key challenges spanned 7 main stakeholders: pharmaceutical industries, drug regulatory agencies, health technology assessment agencies, funders/nongovernmental organizations, healthcare practitioners, patient advocates, and ministries of health/policymakers. These challenges included limited and fragmented epidemiological data, insufficient health economic assessments, manufacturing constraints, complex regulatory frameworks, inefficient distribution systems, poor affordability in low-resource settings, and weak governance structures. Conclusions: These findings underscore the urgent need for a deeper understanding of stakeholder- and context-specific perspectives to address critical gaps and improve antibiotic access in the region.