Vibrio parahaemolyticusAHPND infection altered eicosanoid biosynthesis in the gastrointestinal tract of Litopenaeus vannamei
1
Issued Date
2026-09-01
Resource Type
eISSN
24055808
Scopus ID
2-s2.0-105045376571
Journal Title
Biochemistry and Biophysics Reports
Volume
47
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biochemistry and Biophysics Reports Vol.47 (2026)
Suggested Citation
Wimuttisuk W., Yotbuntueng P., Deenarn P., Tobwor P., Jiemsup S., Yongkiettrakul S., Kittiwongpukdee K., Khidprasert S., Kasamechotchung C., Srichomthong K., Putprasert P. Vibrio parahaemolyticusAHPND infection altered eicosanoid biosynthesis in the gastrointestinal tract of Litopenaeus vannamei. Biochemistry and Biophysics Reports Vol.47 (2026). doi:10.1016/j.bbrep.2026.102721 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/118141
Title
Vibrio parahaemolyticusAHPND infection altered eicosanoid biosynthesis in the gastrointestinal tract of Litopenaeus vannamei
Corresponding Author(s)
Other Contributor(s)
Abstract
Acute Hepatopancreatic Necrosis Disease (AHPND) is one of the main culprits for massive shrimp mortality in the aquaculture industry. AHPND is caused by Vibrio parahaemolyticus (VP<inf>AHPND</inf>) containing plasmids for the PirA and PirB binary toxins. These toxins cause sloughing and cell death in the hepatopancreatic tubules as well as inflammation in the shrimp gastrointestinal tract. Nevertheless, changes in the pro- and anti-inflammatory signaling molecules have yet to be reported. Here, we examined changes in eicosanoid biosynthesis in the Litopenaeus vannamei gastrointestinal tract infected with VP<inf>AHPND</inf> isolate 5HP. At 24 h post-infection, cyclooxygenase enzyme levels increased in the hepatopancreases of VP<inf>AHPND</inf>-infected shrimp. The transcription levels of cytosolic phospholipase A2 were elevated in the intestines of VP<inf>AHPND</inf>-infected shrimp compared with control shrimp. Although the eicosanoid and PUFA profiles were differentially altered in shrimp hepatopancreas, stomach, and intestines, the levels of prostaglandin F<inf>2α</inf> were elevated, whereas the levels of 5-hydroxyeicosapentaenoic acid and 5-hydroxyeicosatetraenoic acid were suppressed in all three organs of VP<inf>AHPND</inf>-infected shrimp. These findings suggest that eicosanoid changes may serve as biomarkers for shrimp gastrointestinal health. Moreover, they indicate the conserved nature of the eicosanoid biosynthesis pathway in the host-pathogen response to bacterial infection in crustaceans.